Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides

Joung Youn Ui, Seul Lee Ye, Jeong Hana, Lee Jun, Joo Won Nam, Jin Lee Yoo, Sook Hwang Eun, Je Hyun Lee, Lee Dongho, Sik Kang Sam, Eun Kyoung Seo

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 μM.

Original languageEnglish
Pages (from-to)1895-1898
Number of pages4
JournalJournal of Natural Products
Volume72
Issue number10
DOIs
Publication statusPublished - 2009 Oct 23

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Ui, J. Y., Ye, S. L., Hana, J., Jun, L., Nam, J. W., Yoo, J. L., Eun, S. H., Lee, J. H., Dongho, L., Sam, S. K., & Seo, E. K. (2009). Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides. Journal of Natural Products, 72(10), 1895-1898. https://doi.org/10.1021/np900397f