Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides

Joung Youn Ui, Seul Lee Ye, Jeong Hana, Lee Jun, Joo Won Nam, Jin Lee Yoo, Sook Hwang Eun, Je Hyun Lee, Dongho Lee, Sik Kang Sam, Eun Kyoung Seo

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Abstract

Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 μM.

Original languageEnglish
Pages (from-to)1895-1898
Number of pages4
JournalJournal of Natural Products
Volume72
Issue number10
DOIs
Publication statusPublished - 2009 Oct 23

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ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Ui, J. Y., Ye, S. L., Hana, J., Jun, L., Nam, J. W., Yoo, J. L., Eun, S. H., Lee, J. H., Lee, D., Sam, S. K., & Seo, E. K. (2009). Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides. Journal of Natural Products, 72(10), 1895-1898. https://doi.org/10.1021/np900397f