Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides

Joung Youn Ui, Seul Lee Ye, Jeong Hana, Lee Jun, Joo Won Nam, Jin Lee Yoo, Sook Hwang Eun, Je Hyun Lee, Dongho Lee, Sik Kang Sam, Eun Kyoung Seo

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 μM.

Original languageEnglish
Pages (from-to)1895-1898
Number of pages4
JournalJournal of Natural Products
Volume72
Issue number10
DOIs
Publication statusPublished - 2009 Oct 23

Fingerprint

Anemarrhena
3T3-L1 Cells
Rhizome
Inhibitory Concentration 50
ethyl acetate
anemarcoumarin A
(E)-4'-demethyl-6-methyleucomin
anemarchalconyn

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Ui, J. Y., Ye, S. L., Hana, J., Jun, L., Nam, J. W., Yoo, J. L., ... Seo, E. K. (2009). Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides. Journal of Natural Products, 72(10), 1895-1898. https://doi.org/10.1021/np900397f

Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides. / Ui, Joung Youn; Ye, Seul Lee; Hana, Jeong; Jun, Lee; Nam, Joo Won; Yoo, Jin Lee; Eun, Sook Hwang; Lee, Je Hyun; Lee, Dongho; Sam, Sik Kang; Seo, Eun Kyoung.

In: Journal of Natural Products, Vol. 72, No. 10, 23.10.2009, p. 1895-1898.

Research output: Contribution to journalArticle

Ui, JY, Ye, SL, Hana, J, Jun, L, Nam, JW, Yoo, JL, Eun, SH, Lee, JH, Lee, D, Sam, SK & Seo, EK 2009, 'Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides', Journal of Natural Products, vol. 72, no. 10, pp. 1895-1898. https://doi.org/10.1021/np900397f
Ui, Joung Youn ; Ye, Seul Lee ; Hana, Jeong ; Jun, Lee ; Nam, Joo Won ; Yoo, Jin Lee ; Eun, Sook Hwang ; Lee, Je Hyun ; Lee, Dongho ; Sam, Sik Kang ; Seo, Eun Kyoung. / Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides. In: Journal of Natural Products. 2009 ; Vol. 72, No. 10. pp. 1895-1898.
@article{68a39d0068d44e88bc9f7bae39cba337,
title = "Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides",
abstract = "Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 μM.",
author = "Ui, {Joung Youn} and Ye, {Seul Lee} and Jeong Hana and Lee Jun and Nam, {Joo Won} and Yoo, {Jin Lee} and Eun, {Sook Hwang} and Lee, {Je Hyun} and Dongho Lee and Sam, {Sik Kang} and Seo, {Eun Kyoung}",
year = "2009",
month = "10",
day = "23",
doi = "10.1021/np900397f",
language = "English",
volume = "72",
pages = "1895--1898",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",
number = "10",

}

TY - JOUR

T1 - Identification of antiadipogenic constituents of the rhizomes of Anemarrhena asphodeloides

AU - Ui, Joung Youn

AU - Ye, Seul Lee

AU - Hana, Jeong

AU - Jun, Lee

AU - Nam, Joo Won

AU - Yoo, Jin Lee

AU - Eun, Sook Hwang

AU - Lee, Je Hyun

AU - Lee, Dongho

AU - Sam, Sik Kang

AU - Seo, Eun Kyoung

PY - 2009/10/23

Y1 - 2009/10/23

N2 - Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 μM.

AB - Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 μM.

UR - http://www.scopus.com/inward/record.url?scp=70350475514&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350475514&partnerID=8YFLogxK

U2 - 10.1021/np900397f

DO - 10.1021/np900397f

M3 - Article

C2 - 19757853

AN - SCOPUS:70350475514

VL - 72

SP - 1895

EP - 1898

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 10

ER -