Identification of cancer cell-line origins using fluorescence image-based phenomic screening

Jun Seok Lee, Yun Kyung Kim, Han Jo Kim, Siti Hajar, Yee Ling Tan, Nam Young Kang, Shin Hui Ng, Chang No Yoon, Young Tae Chang

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Universal phenotyping techniques that can discriminate among various states of biological systems have great potential. We applied 557 fluorescent library compounds to NCI's 60 human cancer cell-lines (NCI-60) to generate a systematic fluorescence phenotypic profiling data. By the kinetic fluorescence intensity analysis, we successfully discriminated the organ origin of all the 60 cell-lines.

Original languageEnglish
Article numbere32096
JournalPloS one
Volume7
Issue number2
DOIs
Publication statusPublished - 2012 Feb 23
Externally publishedYes

ASJC Scopus subject areas

  • General

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