Identification of cancer cell-line origins using fluorescence image-based phenomic screening

Jun Seok Lee; Yun Kyung Kim; Han Jo Kim; Siti Hajar; Yee Ling Tan; Nam Young Kang; Shin Hui Ng; Chang No Yoon; Young Tae Chang

doi:10.1371/journal.pone.0032096

Identification of cancer cell-line origins using fluorescence image-based phenomic screening

Jun Seok Lee, Yun Kyung Kim, Han Jo Kim, Siti Hajar, Yee Ling Tan, Nam Young Kang, Shin Hui Ng, Chang No Yoon, Young Tae Chang

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Universal phenotyping techniques that can discriminate among various states of biological systems have great potential. We applied 557 fluorescent library compounds to NCI's 60 human cancer cell-lines (NCI-60) to generate a systematic fluorescence phenotypic profiling data. By the kinetic fluorescence intensity analysis, we successfully discriminated the organ origin of all the 60 cell-lines.

Original language	English
Article number	e32096
Journal	PloS one
Volume	7
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0032096
Publication status	Published - 2012 Feb 23
Externally published	Yes

ASJC Scopus subject areas

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UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0032096

Cite this

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abstract = "Universal phenotyping techniques that can discriminate among various states of biological systems have great potential. We applied 557 fluorescent library compounds to NCI's 60 human cancer cell-lines (NCI-60) to generate a systematic fluorescence phenotypic profiling data. By the kinetic fluorescence intensity analysis, we successfully discriminated the organ origin of all the 60 cell-lines.",

author = "Lee, {Jun Seok} and Kim, {Yun Kyung} and Kim, {Han Jo} and Siti Hajar and Tan, {Yee Ling} and Kang, {Nam Young} and Ng, {Shin Hui} and Yoon, {Chang No} and Chang, {Young Tae}",

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AU - Lee, Jun Seok

AU - Kim, Yun Kyung

AU - Kim, Han Jo

AU - Hajar, Siti

AU - Tan, Yee Ling

AU - Kang, Nam Young

AU - Ng, Shin Hui

AU - Yoon, Chang No

AU - Chang, Young Tae

PY - 2012/2/23

Y1 - 2012/2/23

N2 - Universal phenotyping techniques that can discriminate among various states of biological systems have great potential. We applied 557 fluorescent library compounds to NCI's 60 human cancer cell-lines (NCI-60) to generate a systematic fluorescence phenotypic profiling data. By the kinetic fluorescence intensity analysis, we successfully discriminated the organ origin of all the 60 cell-lines.

AB - Universal phenotyping techniques that can discriminate among various states of biological systems have great potential. We applied 557 fluorescent library compounds to NCI's 60 human cancer cell-lines (NCI-60) to generate a systematic fluorescence phenotypic profiling data. By the kinetic fluorescence intensity analysis, we successfully discriminated the organ origin of all the 60 cell-lines.

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JO - PLoS One

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SN - 1932-6203

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Identification of cancer cell-line origins using fluorescence image-based phenomic screening

Abstract

ASJC Scopus subject areas

UN SDGs

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