Identification of Dioscorea batatas (Sanyak) allergen as an inhalant and oral allergen

Gyu Young Hur, Han Jung Park, Hyoun Ah Kim, Young Min Ye, Hae Sim Park

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Dioscorea batatas is widely used in Asia as a herbal medicine or food product with potential health benefits. There have been several reports of occupational asthma caused by inhalation of D. batatas dust. However, there has been no report of systemic allergic reactions after oral administration of D. batatas. Two patients with D. batatas allergy were enrolled. One had experienced severe urticaria and angioedema after indigestion, and the other had been exposed to D. batatas dust and was diagnosed as having occupational asthma. Both patients had high serum-specific IgE and IgG4 antibodies to D. batatas. And IgE immunoblot demonstrated that both sera bound to a 27-kDa protein with an IgE-binding motif, which was revealed by 2-D-electrophoresis to have the sequence Asn-Val-Glu-Asp-Glu-Phe-Ser-X-Ile-Glu-Gly-Asn-Pro-X-X-Pro-Glu-Asn-X-Gly (pI 6.40, 6.04). In conclusion, discorin from D. batatas (DB3S) was identified as the major allergen of D. batatas in patients sensitized via an oral or inhalant route.

Original languageEnglish
Pages (from-to)72-76
Number of pages5
JournalJournal of Korean medical science
Issue number1
Publication statusPublished - 2008 Feb
Externally publishedYes


  • Allergen
  • Dioscorea batatas
  • Food hypersensitivity
  • Inhalant allergy
  • Sanyak

ASJC Scopus subject areas

  • Medicine(all)


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