Identification of infants at risk for autism using multi-parameter hierarchical white matter connectomes

Infant Brain Imaging Study (IBIS) Network

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

Autism spectrum disorder (ASD) is a variety of developmental disorders that cause life-long communication and social deficits. However, ASD could only be diagnosed at children as early as 2 years of age, while early signs may emerge within the first year. White matter (WM) connectivity abnormalities have been documented in the first year of lives of ASD subjects. We introduce a novel multi-kernel support vector machine (SVM) framework to identify infants at high-risk for ASD at 6 months old, by utilizing the diffusion parameters derived from a hierarchical set of WM connectomes. Experiments show that the proposed method achieves an accuracy of 76%, in comparison to 70% with the best single connectome. The complementary information extracted from hierarchical networks enhances the classification performance, with the top discriminative connections consistent with other studies. Our framework provides essential imaging connectomic markers and contributes to the evaluation of ASD risks as early as 6 months.

Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
PublisherSpringer Verlag
Pages170-177
Number of pages8
Volume9352
ISBN (Print)9783319248875
DOIs
Publication statusPublished - 2015
Externally publishedYes
Event6th International Workshop on Machine Learning in Medical Imaging, MLMI 2015 and Held in Conjunction with 18th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2015 - Munich, Germany
Duration: 2015 Oct 52015 Oct 5

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9352
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other6th International Workshop on Machine Learning in Medical Imaging, MLMI 2015 and Held in Conjunction with 18th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2015
CountryGermany
CityMunich
Period15/10/515/10/5

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

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    Infant Brain Imaging Study (IBIS) Network (2015). Identification of infants at risk for autism using multi-parameter hierarchical white matter connectomes. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 9352, pp. 170-177). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 9352). Springer Verlag. https://doi.org/10.1007/978-3-319-24888-2_21