Identification of intra-cellular feedback loops by intermittent step perturbation method

Chaoyi Dong, Kwang Hyun Cho, Tae Woong Yoon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Feedback loops play pivotal roles in the regulation and control of many important cellular processes such as gene transcription, signal transduction, and metabolism. Hence, identification of feedback loops embedded in biomolecular regulatory networks is crucial to understanding the regulatory mechanisms underlying various cellular processes. In this paper, we introduce an identification method called the intermittent step perturbation method (ISPM) that can efficiently identify and locate feedback connectivities among reacting biomolecules. In particular, a sort of stochastic function called an intermittent step perturbation is applied to excite a given network. Then, we employ a statistical algorithm to analyze the resulting time-series data, thereby discerning any causal connection with a circular causal property. This circular causal property implies the existence of a feedback loop in the regulatory network. Finally, the proposed ISPM is demonstrated through an insulin signal transduction pathway model.

Original languageEnglish
Title of host publicationIFAC Proceedings Volumes (IFAC-PapersOnline)
Volume17
Edition1 PART 1
DOIs
Publication statusPublished - 2008 Dec 1
Event17th World Congress, International Federation of Automatic Control, IFAC - Seoul, Korea, Republic of
Duration: 2008 Jul 62008 Jul 11

Other

Other17th World Congress, International Federation of Automatic Control, IFAC
CountryKorea, Republic of
CitySeoul
Period08/7/608/7/11

Fingerprint

Feedback
Signal transduction
Insulin
Biomolecules
Transcription
Metabolism
Time series
Genes

Keywords

  • Control in system biology

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Dong, C., Cho, K. H., & Yoon, T. W. (2008). Identification of intra-cellular feedback loops by intermittent step perturbation method. In IFAC Proceedings Volumes (IFAC-PapersOnline) (1 PART 1 ed., Vol. 17) https://doi.org/10.3182/20080706-5-KR-1001.1224

Identification of intra-cellular feedback loops by intermittent step perturbation method. / Dong, Chaoyi; Cho, Kwang Hyun; Yoon, Tae Woong.

IFAC Proceedings Volumes (IFAC-PapersOnline). Vol. 17 1 PART 1. ed. 2008.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dong, C, Cho, KH & Yoon, TW 2008, Identification of intra-cellular feedback loops by intermittent step perturbation method. in IFAC Proceedings Volumes (IFAC-PapersOnline). 1 PART 1 edn, vol. 17, 17th World Congress, International Federation of Automatic Control, IFAC, Seoul, Korea, Republic of, 08/7/6. https://doi.org/10.3182/20080706-5-KR-1001.1224
Dong, Chaoyi ; Cho, Kwang Hyun ; Yoon, Tae Woong. / Identification of intra-cellular feedback loops by intermittent step perturbation method. IFAC Proceedings Volumes (IFAC-PapersOnline). Vol. 17 1 PART 1. ed. 2008.
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