Identification of intra-cellular feedback loops by intermittent step perturbation method

Chaoyi Dong, Kwang Hyun Cho, Tae Woong Yoon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Feedback loops play pivotal roles in the regulation and control of many important cellular processes such as gene transcription, signal transduction, and metabolism. Hence, identification of feedback loops embedded in biomolecular regulatory networks is crucial to understanding the regulatory mechanisms underlying various cellular processes. In this paper, we introduce an identification method called the intermittent step perturbation method (ISPM) that can efficiently identify and locate feedback connectivities among reacting biomolecules. In particular, a sort of stochastic function called an intermittent step perturbation is applied to excite a given network. Then, we employ a statistical algorithm to analyze the resulting time-series data, thereby discerning any causal connection with a circular causal property. This circular causal property implies the existence of a feedback loop in the regulatory network. Finally, the proposed ISPM is demonstrated through an insulin signal transduction pathway model.

Original languageEnglish
Title of host publicationProceedings of the 17th World Congress, International Federation of Automatic Control, IFAC
Edition1 PART 1
DOIs
Publication statusPublished - 2008
Event17th World Congress, International Federation of Automatic Control, IFAC - Seoul, Korea, Republic of
Duration: 2008 Jul 62008 Jul 11

Publication series

NameIFAC Proceedings Volumes (IFAC-PapersOnline)
Number1 PART 1
Volume17
ISSN (Print)1474-6670

Other

Other17th World Congress, International Federation of Automatic Control, IFAC
CountryKorea, Republic of
CitySeoul
Period08/7/608/7/11

Keywords

  • Control in system biology

ASJC Scopus subject areas

  • Control and Systems Engineering

Fingerprint Dive into the research topics of 'Identification of intra-cellular feedback loops by intermittent step perturbation method'. Together they form a unique fingerprint.

  • Cite this

    Dong, C., Cho, K. H., & Yoon, T. W. (2008). Identification of intra-cellular feedback loops by intermittent step perturbation method. In Proceedings of the 17th World Congress, International Federation of Automatic Control, IFAC (1 PART 1 ed.). (IFAC Proceedings Volumes (IFAC-PapersOnline); Vol. 17, No. 1 PART 1). https://doi.org/10.3182/20080706-5-KR-1001.1224