Abstract
Feedback loops play pivotal roles in the regulation and control of many important cellular processes such as gene transcription, signal transduction, and metabolism. Hence, identification of feedback loops embedded in biomolecular regulatory networks is crucial to understanding the regulatory mechanisms underlying various cellular processes. In this paper, we introduce an identification method called the intermittent step perturbation method (ISPM) that can efficiently identify and locate feedback connectivities among reacting biomolecules. In particular, a sort of stochastic function called an intermittent step perturbation is applied to excite a given network. Then, we employ a statistical algorithm to analyze the resulting time-series data, thereby discerning any causal connection with a circular causal property. This circular causal property implies the existence of a feedback loop in the regulatory network. Finally, the proposed ISPM is demonstrated through an insulin signal transduction pathway model.
| Original language | English |
|---|---|
| Title of host publication | IFAC Proceedings Volumes (IFAC-PapersOnline) |
| Volume | 17 |
| Edition | 1 PART 1 |
| DOIs | |
| Publication status | Published - 2008 Dec 1 |
| Event | 17th World Congress, International Federation of Automatic Control, IFAC - Seoul, Korea, Republic of Duration: 2008 Jul 6 → 2008 Jul 11 |
Other
| Other | 17th World Congress, International Federation of Automatic Control, IFAC |
|---|---|
| Country | Korea, Republic of |
| City | Seoul |
| Period | 08/7/6 → 08/7/11 |
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Keywords
- Control in system biology
ASJC Scopus subject areas
- Control and Systems Engineering
Cite this
Identification of intra-cellular feedback loops by intermittent step perturbation method. / Dong, Chaoyi; Cho, Kwang Hyun; Yoon, Tae Woong.
IFAC Proceedings Volumes (IFAC-PapersOnline). Vol. 17 1 PART 1. ed. 2008.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Identification of intra-cellular feedback loops by intermittent step perturbation method
AU - Dong, Chaoyi
AU - Cho, Kwang Hyun
AU - Yoon, Tae Woong
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Feedback loops play pivotal roles in the regulation and control of many important cellular processes such as gene transcription, signal transduction, and metabolism. Hence, identification of feedback loops embedded in biomolecular regulatory networks is crucial to understanding the regulatory mechanisms underlying various cellular processes. In this paper, we introduce an identification method called the intermittent step perturbation method (ISPM) that can efficiently identify and locate feedback connectivities among reacting biomolecules. In particular, a sort of stochastic function called an intermittent step perturbation is applied to excite a given network. Then, we employ a statistical algorithm to analyze the resulting time-series data, thereby discerning any causal connection with a circular causal property. This circular causal property implies the existence of a feedback loop in the regulatory network. Finally, the proposed ISPM is demonstrated through an insulin signal transduction pathway model.
AB - Feedback loops play pivotal roles in the regulation and control of many important cellular processes such as gene transcription, signal transduction, and metabolism. Hence, identification of feedback loops embedded in biomolecular regulatory networks is crucial to understanding the regulatory mechanisms underlying various cellular processes. In this paper, we introduce an identification method called the intermittent step perturbation method (ISPM) that can efficiently identify and locate feedback connectivities among reacting biomolecules. In particular, a sort of stochastic function called an intermittent step perturbation is applied to excite a given network. Then, we employ a statistical algorithm to analyze the resulting time-series data, thereby discerning any causal connection with a circular causal property. This circular causal property implies the existence of a feedback loop in the regulatory network. Finally, the proposed ISPM is demonstrated through an insulin signal transduction pathway model.
KW - Control in system biology
UR - http://www.scopus.com/inward/record.url?scp=79961019580&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79961019580&partnerID=8YFLogxK
U2 - 10.3182/20080706-5-KR-1001.1224
DO - 10.3182/20080706-5-KR-1001.1224
M3 - Conference contribution
AN - SCOPUS:79961019580
SN - 9783902661005
VL - 17
BT - IFAC Proceedings Volumes (IFAC-PapersOnline)
ER -