Identification of novel electroconvulsive shock-induced and activity-dependent genes in the rat brain

Woong Sun, Kun Woo Park, Jeehyung Choe, Im Joo Rhyu, Il Hwan Kim, Soon Kwon Park, Byungil Choi, Sang-Hyun Choi, Sun-Hwa Park, Hyun Kim

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Electroconvulsive shock (ECS) has been used as an effective treatment for patients suffering from major depression disorders and schizophrenia. However, the exact mechanisms underlying the action of ECS are poorly understood. Using high-density oligonucleotide microarrays, we identified 60 ECS-induced genes whose gene products are involved in the neuronal signaling, neuritogenesis and tissue remodeling. In situ hybridization and depolarization-dependent expression assay were performed to characterize 4 genes (lysyl oxidase, Ab1-046, SOX11, and T-type calcium channel 1G subunit) which have not yet been reported to be induced by ECS. Interestingly, the induction of these genes was observed mainly in the dentate gyrus of hippocampal formation and piriform cortex, where ECS-induced neural activation is highlighted, and depolarization of cultured cortical neurons also induced the expression of these genes. Taken together, our results suggest that therapeutic actions of ECS may be manifested by the activity-dependent induction of genes related to the plastic changes of the brain such as neuronal signaling neuritogenesis, and tissue remodeling.

Original languageEnglish
Pages (from-to)848-856
Number of pages9
JournalBiochemical and Biophysical Research Communications
Volume327
Issue number3
DOIs
Publication statusPublished - 2005 Feb 18

Fingerprint

Electroshock
Rats
Brain
Genes
Depolarization
T-Type Calcium Channels
Protein-Lysine 6-Oxidase
Tissue
Dentate Gyrus
Microarrays
Oligonucleotide Array Sequence Analysis
Oligonucleotides
Neurons
In Situ Hybridization
Assays
Hippocampus
Schizophrenia
Chemical activation
Depression
Gene Expression

Keywords

  • Electroconvulsive shock
  • Microarray
  • Neural activity
  • Tissue remodeling

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Identification of novel electroconvulsive shock-induced and activity-dependent genes in the rat brain. / Sun, Woong; Park, Kun Woo; Choe, Jeehyung; Rhyu, Im Joo; Kim, Il Hwan; Park, Soon Kwon; Choi, Byungil; Choi, Sang-Hyun; Park, Sun-Hwa; Kim, Hyun.

In: Biochemical and Biophysical Research Communications, Vol. 327, No. 3, 18.02.2005, p. 848-856.

Research output: Contribution to journalArticle

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