Identification of tail binding effect of kinesin-1 using an elastic network model

Jae In Kim, Hyun Joon Chang, Sung Soo Na

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Kinesin is a motor protein that delivers cargo inside a cell. Kinesin has many different families, but they perform basically same function and have same motions. The walking motion of kinesin enables the cargo delivery inside the cell. Autoinhibition of kinesin is important because it explains how function of kinesin inside a cell is stopped. Former researches showed that tail binding is related to autoinhibition of kinesin. In this work, we performed normal mode analysis with elastic network model using different conformation of kinesin to determine the effect of tail binding by considering four models such as functional form, autoinhibited form, autoinhibited form without tail, and autoinhibited form with carbon structure. Our calculation of the thermal fluctuation and cross-correlation shows the change of tail-binding region in structural motion. Also strain energy of kinesin showed that elimination of tail binding effect leads the structure to have energetically similar behavior with the functional form.

Original languageEnglish
Pages (from-to)1107-1117
Number of pages11
JournalBiomechanics and Modeling in Mechanobiology
Volume14
Issue number5
DOIs
Publication statusPublished - 2015 Oct 13

Keywords

  • Autoinhibition
  • Elastic network model
  • Kinesin
  • Normal mode analysis

ASJC Scopus subject areas

  • Biotechnology
  • Mechanical Engineering
  • Modelling and Simulation

Fingerprint Dive into the research topics of 'Identification of tail binding effect of kinesin-1 using an elastic network model'. Together they form a unique fingerprint.

  • Cite this