Identification of the Vibrio vulnificus wbpP gene and evaluation of its role in virulence

Na Young Park, Jeong Hyun Lee, Myung Won Kim, Hee Gon Jeong, Byung Cheol Lee, Tae Sung Kim, Sang Ho Choi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A wbpP gene encoding a putative UDP-N-acetyl-D-glucosamine C4 epimerase was identified and cloned from Vibrio vulnificus. The functions of the wbpP gene, assessed by the construction of an isogenic mutant and by evaluating its phenotype changes, demonstrated that WbpP is essential in both the pathogenesis and the capsular polysaccharide biosynthesis of V. vulnificus.

Original languageEnglish
Pages (from-to)721-728
Number of pages8
JournalInfection and Immunity
Volume74
Issue number1
DOIs
Publication statusPublished - 2006 Jan 1

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Vibrio vulnificus
Virulence
Racemases and Epimerases
Uridine Diphosphate
Acetylglucosamine
Genes
Polysaccharides
Phenotype

ASJC Scopus subject areas

  • Immunology

Cite this

Identification of the Vibrio vulnificus wbpP gene and evaluation of its role in virulence. / Park, Na Young; Lee, Jeong Hyun; Kim, Myung Won; Jeong, Hee Gon; Lee, Byung Cheol; Kim, Tae Sung; Choi, Sang Ho.

In: Infection and Immunity, Vol. 74, No. 1, 01.01.2006, p. 721-728.

Research output: Contribution to journalArticle

Park, Na Young ; Lee, Jeong Hyun ; Kim, Myung Won ; Jeong, Hee Gon ; Lee, Byung Cheol ; Kim, Tae Sung ; Choi, Sang Ho. / Identification of the Vibrio vulnificus wbpP gene and evaluation of its role in virulence. In: Infection and Immunity. 2006 ; Vol. 74, No. 1. pp. 721-728.
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