Identification of tissue-specific targeting peptide.

Eunkyoung Jung, Nam Kyung Lee, Sang Kee Kang, Seung Hoon Choi, Daejin Kim, Kisoo Park, Kihang Choi, Yun Jaie Choi, Dong Hyun Jung

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Using phage display technique, we identified tissue-targeting peptide sets that recognize specific tissues (bone-marrow dendritic cell, kidney, liver, lung, spleen and visceral adipose tissue). In order to rapidly evaluate tissue-specific targeting peptides, we performed machine learning studies for predicting the tissue-specific targeting activity of peptides on the basis of peptide sequence information using four machine learning models and isolated the groups of peptides capable of mediating selective targeting to specific tissues. As a representative liver-specific targeting sequence, the peptide "DKNLQLH" was selected by the sequence similarity analysis. This peptide has a high degree of homology with protein ligands which can interact with corresponding membrane counterparts. We anticipate that our models will be applicable to the prediction of tissue-specific targeting peptides which can recognize the endothelial markers of target tissues.

Original languageEnglish
Pages (from-to)1267-1275
Number of pages9
JournalJournal of Computer-Aided Molecular Design
Volume26
Issue number11
Publication statusPublished - 2012 Nov 1

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ASJC Scopus subject areas

  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Computer Science Applications

Cite this

Jung, E., Lee, N. K., Kang, S. K., Choi, S. H., Kim, D., Park, K., Choi, K., Choi, Y. J., & Jung, D. H. (2012). Identification of tissue-specific targeting peptide. Journal of Computer-Aided Molecular Design, 26(11), 1267-1275.