TY - JOUR
T1 - Identification of two new phenanthrenes from Dendrobii herba and their cytotoxicity towards human hypopharynx squamous carcinoma cell (FadU)
AU - Nam, Bomi
AU - Ryu, Seung Mok
AU - Lee, Dongho
AU - Jung, Chan Hun
AU - Jin, Chang Hyun
AU - Kim, Jin Baek
AU - Lee, Ik Soo
AU - Han, Ah Reum
N1 - Funding Information:
Funding: This work was supported by grants from the Korea Atomic Energy Research Institute (KAERI) and the National Research Foundation of Korea (2017R1C1B2006273).
PY - 2019
Y1 - 2019
N2 - Two new phenanthrenes, (1R,2R)-1,7-hydroxy-2,8-methoxy-2,3-dihydrophenanthrene-4(1H)-one (1) and 2,7-dihydroxy-phenanthrene-1,4-dione (2), were isolated from the ethyl acetate-soluble fraction of Dendrobii Herba, together with seven known phenanthrenes (3–9), two bibenzyls (10–12), and a lignan (13). Structures of 1 and 2 were elucidated by analyzing one-dimensional (1D) and two-dimensional (2D)-NMR and High-resolution electrospray ionization mass spectra (HR-ESI-MS) data. The absolute configuration of compound 1 was confirmed by the circular dichroism (CD) spectroscopic method. In cytotoxicity assay using FaDu human hypopharynx squamous carcinoma cell line, compounds 3–6, 8, 10, and 12 showed activities, with IC50 values that ranged from 2.55 to 17.70 µM.
AB - Two new phenanthrenes, (1R,2R)-1,7-hydroxy-2,8-methoxy-2,3-dihydrophenanthrene-4(1H)-one (1) and 2,7-dihydroxy-phenanthrene-1,4-dione (2), were isolated from the ethyl acetate-soluble fraction of Dendrobii Herba, together with seven known phenanthrenes (3–9), two bibenzyls (10–12), and a lignan (13). Structures of 1 and 2 were elucidated by analyzing one-dimensional (1D) and two-dimensional (2D)-NMR and High-resolution electrospray ionization mass spectra (HR-ESI-MS) data. The absolute configuration of compound 1 was confirmed by the circular dichroism (CD) spectroscopic method. In cytotoxicity assay using FaDu human hypopharynx squamous carcinoma cell line, compounds 3–6, 8, 10, and 12 showed activities, with IC50 values that ranged from 2.55 to 17.70 µM.
KW - (1R,2R)-1,7-hydroxy-2,8-methoxy-2,3-dihydrophenanthrene-4(1H)-one
KW - 2,7-dihydroxy-phenanthrene-1,4-dione
KW - Cytotoxicity
KW - Dendrobii Herb
KW - FaDu human hypopharynx squamous carcinoma cell
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U2 - 10.3390/molecules24122339
DO - 10.3390/molecules24122339
M3 - Article
C2 - 31242649
AN - SCOPUS:85068125613
VL - 24
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 12
M1 - 2339
ER -