Identifying high order brain connectome biomarkers via learning on hypergraph

Chen Zu, Yue Gao, Brent Munsell, Minjeong Kim, Ziwen Peng, Yingying Zhu, Wei Gao, Daoqiang Zhang, Dinggang Shen, Guorong Wu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The functional connectome has gained increased attention in the neuroscience community. In general, most network connectivity models are based on correlations between discrete-time series signals that only connect two different brain regions. However, these bivariate region-to-region models do not involve three or more brain regions that form a subnetwork. Here we propose a learning-based method to explore subnetwork biomarkers that are significantly distinguishable between two clinical cohorts. Learning on hypergraph is employed in our work. Specifically, we construct a hypergraph by exhaustively inspecting all possible subnetworks for all subjects, where each hyperedge connects a group of subjects demonstrating highly correlated functional connectivity behavior throughout the underlying subnetwork. The objective function of hypergraph learning is to jointly optimize the weights for all hyperedges which make the separation of two groups by the learned data representation be in the best consensus with the observed clinical labels. We deploy our method to find high order childhood autism biomarkers from rs-fMRI images. Promising results have been obtained from comprehensive evaluation on the discriminative power and generality in diagnosis of Autism.

Original languageEnglish
Title of host publicationMachine Learning in Medical Imaging - 7th International Workshop, MLMI 2016 held in conjunction with MICCAI 2016, Proceedings
EditorsLi Wang, Heung-Il Suk, Yinghuan Shi, Ehsan Adeli, Qian Wang
PublisherSpringer Verlag
Pages1-9
Number of pages9
ISBN (Print)9783319471563
DOIs
Publication statusPublished - 2016
Externally publishedYes
Event7th International Workshop on Machine Learning in Medical Imaging, MLMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016 - Athens, Greece
Duration: 2016 Oct 172016 Oct 17

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume10019 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other7th International Workshop on Machine Learning in Medical Imaging, MLMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016
CountryGreece
CityAthens
Period16/10/1716/10/17

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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  • Cite this

    Zu, C., Gao, Y., Munsell, B., Kim, M., Peng, Z., Zhu, Y., Gao, W., Zhang, D., Shen, D., & Wu, G. (2016). Identifying high order brain connectome biomarkers via learning on hypergraph. In L. Wang, H-I. Suk, Y. Shi, E. Adeli, & Q. Wang (Eds.), Machine Learning in Medical Imaging - 7th International Workshop, MLMI 2016 held in conjunction with MICCAI 2016, Proceedings (pp. 1-9). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 10019 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-319-47157-0_1