Abstract
Background and Purpose Estimating age- and sex-specific population attributable risks (PARs) of major risk factors for stroke may be a useful strategy to identify risk factors for targeting preventive strategies. Methods For this case-control matched study, consecutive patients aged 18-90 years and admitted to nine nationwide hospitals with acute ischemic stroke between December 2008 and June 2010, were enrolled as cases. Controls, individually matched by age and sex, were chosen from the 4th Korean National Health & Nutrition Examination Survey (2008-2010). Based on odds ratios and prevalence, standardized according to the age and sex structure of the Korean population, PARs of major risk factors were estimated according to age (young, ≤45; middle-aged, 46-65; and elderly, ≥66 years) and sex subgroups. Results In 4,743 matched case-control sets, smoking (PAR, 45.1%) was the greatest contributing risk factor in young men, followed by hypertension (28.5%). In middle-aged men, the greatest contributing factors were smoking (37.4%), hypertension (22.7%), and diabetes (14.6%), whereas in women the greatest factors were hypertension (22.7%) and stroke history (10.6%). In the elderly, hypertension was the leading factor in men (23.7%) and women (23.4%). Other noticeable factors were stroke history (men, 19.7%; women, 17.3%) and diabetes (men, 12.5%; women, 15.1%). In young women, risk factors with a PAR greater than 10% were not found. Conclusions Smoking cessation in young people and hypertension and diabetes control in older people may be effective in reducing the burden of stroke on the population. In the elderly, secondary prevention could also be emphasized.
| Original language | English |
|---|---|
| Pages (from-to) | 302-311 |
| Number of pages | 10 |
| Journal | Journal of Stroke |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2015 Sep 1 |
Fingerprint
Keywords
- Ischemic stroke
- Population attributable risk
- Risk factor
ASJC Scopus subject areas
- Clinical Neurology
- Cardiology and Cardiovascular Medicine
Cite this
Identifying target risk factors using population attributable risks of ischemic stroke by age and sex. / Park, Tai Hwan; Ko, Youngchai; Lee, Soo Joo; Lee, Kyung Bok; Lee, Jun; Han, Moon Ku; Park, Jong Moo; Cho, Yong Jin; Hong, Keun Sik; Kim, Dae Hyun; Cha, Jae Kwan; Oh, Mi Sun; Yu, Kyung Ho; Lee, Byung Chul; Yoo, Byung Woo; Lee, Ji Sung; Lee, Juneyoung; Bae, Hee Joon.
In: Journal of Stroke, Vol. 17, No. 3, 01.09.2015, p. 302-311.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Identifying target risk factors using population attributable risks of ischemic stroke by age and sex
AU - Park, Tai Hwan
AU - Ko, Youngchai
AU - Lee, Soo Joo
AU - Lee, Kyung Bok
AU - Lee, Jun
AU - Han, Moon Ku
AU - Park, Jong Moo
AU - Cho, Yong Jin
AU - Hong, Keun Sik
AU - Kim, Dae Hyun
AU - Cha, Jae Kwan
AU - Oh, Mi Sun
AU - Yu, Kyung Ho
AU - Lee, Byung Chul
AU - Yoo, Byung Woo
AU - Lee, Ji Sung
AU - Lee, Juneyoung
AU - Bae, Hee Joon
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Background and Purpose Estimating age- and sex-specific population attributable risks (PARs) of major risk factors for stroke may be a useful strategy to identify risk factors for targeting preventive strategies. Methods For this case-control matched study, consecutive patients aged 18-90 years and admitted to nine nationwide hospitals with acute ischemic stroke between December 2008 and June 2010, were enrolled as cases. Controls, individually matched by age and sex, were chosen from the 4th Korean National Health & Nutrition Examination Survey (2008-2010). Based on odds ratios and prevalence, standardized according to the age and sex structure of the Korean population, PARs of major risk factors were estimated according to age (young, ≤45; middle-aged, 46-65; and elderly, ≥66 years) and sex subgroups. Results In 4,743 matched case-control sets, smoking (PAR, 45.1%) was the greatest contributing risk factor in young men, followed by hypertension (28.5%). In middle-aged men, the greatest contributing factors were smoking (37.4%), hypertension (22.7%), and diabetes (14.6%), whereas in women the greatest factors were hypertension (22.7%) and stroke history (10.6%). In the elderly, hypertension was the leading factor in men (23.7%) and women (23.4%). Other noticeable factors were stroke history (men, 19.7%; women, 17.3%) and diabetes (men, 12.5%; women, 15.1%). In young women, risk factors with a PAR greater than 10% were not found. Conclusions Smoking cessation in young people and hypertension and diabetes control in older people may be effective in reducing the burden of stroke on the population. In the elderly, secondary prevention could also be emphasized.
AB - Background and Purpose Estimating age- and sex-specific population attributable risks (PARs) of major risk factors for stroke may be a useful strategy to identify risk factors for targeting preventive strategies. Methods For this case-control matched study, consecutive patients aged 18-90 years and admitted to nine nationwide hospitals with acute ischemic stroke between December 2008 and June 2010, were enrolled as cases. Controls, individually matched by age and sex, were chosen from the 4th Korean National Health & Nutrition Examination Survey (2008-2010). Based on odds ratios and prevalence, standardized according to the age and sex structure of the Korean population, PARs of major risk factors were estimated according to age (young, ≤45; middle-aged, 46-65; and elderly, ≥66 years) and sex subgroups. Results In 4,743 matched case-control sets, smoking (PAR, 45.1%) was the greatest contributing risk factor in young men, followed by hypertension (28.5%). In middle-aged men, the greatest contributing factors were smoking (37.4%), hypertension (22.7%), and diabetes (14.6%), whereas in women the greatest factors were hypertension (22.7%) and stroke history (10.6%). In the elderly, hypertension was the leading factor in men (23.7%) and women (23.4%). Other noticeable factors were stroke history (men, 19.7%; women, 17.3%) and diabetes (men, 12.5%; women, 15.1%). In young women, risk factors with a PAR greater than 10% were not found. Conclusions Smoking cessation in young people and hypertension and diabetes control in older people may be effective in reducing the burden of stroke on the population. In the elderly, secondary prevention could also be emphasized.
KW - Ischemic stroke
KW - Population attributable risk
KW - Risk factor
UR - http://www.scopus.com/inward/record.url?scp=84942889458&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942889458&partnerID=8YFLogxK
U2 - 10.5853/jos.2015.17.3.302
DO - 10.5853/jos.2015.17.3.302
M3 - Review article
AN - SCOPUS:84942889458
VL - 17
SP - 302
EP - 311
JO - Journal of Stroke
JF - Journal of Stroke
SN - 2287-6391
IS - 3
ER -