TY - JOUR
T1 - Idiopathic inflammatory myopathy and the risk of venous thromboembolism
T2 - a meta-analysis
AU - Lee, Young Ho
AU - Song, Gwan Gyu
N1 - Publisher Copyright:
© 2017, Springer-Verlag Berlin Heidelberg.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - This study aimed at analyzing published data on the association between idiopathic inflammatory myopathy and venous thromboembolism (VTE). We examined studies on VTE risk in patients with polymyositis (PM) and/or dermatomyositis (DM), in the MEDLINE, EMBASE, and Cochrane databases and via manual searches. We performed a meta-analysis on the relative risks (RRs) of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in these patients. Five studies, including 8858 patients with PM/DM met the inclusion criteria. Meta-analysis revealed a significant association between PM/DM and VTE risk (RR = 4.364, 95% CI 2.128–8.949, p = 5.8 × 10−5). A significant association was found between PE risk and PM/DM (RR = 3.504, 95% CI 2.856–4.300, p < 1.0 × 10−8). Meta-analysis also indicated a significant association between DVT risk and PM/DM (RR = 7.481, 95% CI 3.355–16.68, p = 8.7 × 10−7). This meta-analysis demonstrated that both types of PM/DM are associated with an elevated risk of VTE, PE, and DVT, suggesting that patients with PM/DM should be carefully monitored for development of these conditions.
AB - This study aimed at analyzing published data on the association between idiopathic inflammatory myopathy and venous thromboembolism (VTE). We examined studies on VTE risk in patients with polymyositis (PM) and/or dermatomyositis (DM), in the MEDLINE, EMBASE, and Cochrane databases and via manual searches. We performed a meta-analysis on the relative risks (RRs) of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in these patients. Five studies, including 8858 patients with PM/DM met the inclusion criteria. Meta-analysis revealed a significant association between PM/DM and VTE risk (RR = 4.364, 95% CI 2.128–8.949, p = 5.8 × 10−5). A significant association was found between PE risk and PM/DM (RR = 3.504, 95% CI 2.856–4.300, p < 1.0 × 10−8). Meta-analysis also indicated a significant association between DVT risk and PM/DM (RR = 7.481, 95% CI 3.355–16.68, p = 8.7 × 10−7). This meta-analysis demonstrated that both types of PM/DM are associated with an elevated risk of VTE, PE, and DVT, suggesting that patients with PM/DM should be carefully monitored for development of these conditions.
KW - Dermatomyositis
KW - Polymyositis
KW - Venous thromboembolism
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U2 - 10.1007/s00296-017-3735-0
DO - 10.1007/s00296-017-3735-0
M3 - Article
C2 - 28493173
AN - SCOPUS:85019099941
VL - 37
SP - 1165
EP - 1173
JO - Rheumatology International
JF - Rheumatology International
SN - 0172-8172
IS - 7
ER -