Idiopathic inflammatory myopathy and the risk of venous thromboembolism: a meta-analysis

Young Ho Lee, Gwan Gyu Song

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    This study aimed at analyzing published data on the association between idiopathic inflammatory myopathy and venous thromboembolism (VTE). We examined studies on VTE risk in patients with polymyositis (PM) and/or dermatomyositis (DM), in the MEDLINE, EMBASE, and Cochrane databases and via manual searches. We performed a meta-analysis on the relative risks (RRs) of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in these patients. Five studies, including 8858 patients with PM/DM met the inclusion criteria. Meta-analysis revealed a significant association between PM/DM and VTE risk (RR = 4.364, 95% CI 2.128–8.949, p = 5.8 × 10−5). A significant association was found between PE risk and PM/DM (RR = 3.504, 95% CI 2.856–4.300, p < 1.0 × 10−8). Meta-analysis also indicated a significant association between DVT risk and PM/DM (RR = 7.481, 95% CI 3.355–16.68, p = 8.7 × 10−7). This meta-analysis demonstrated that both types of PM/DM are associated with an elevated risk of VTE, PE, and DVT, suggesting that patients with PM/DM should be carefully monitored for development of these conditions.

    Original languageEnglish
    Pages (from-to)1165-1173
    Number of pages9
    JournalRheumatology International
    Volume37
    Issue number7
    DOIs
    Publication statusPublished - 2017 Jul 1

    Keywords

    • Dermatomyositis
    • Polymyositis
    • Venous thromboembolism

    ASJC Scopus subject areas

    • Rheumatology
    • Immunology and Allergy
    • Immunology

    Fingerprint

    Dive into the research topics of 'Idiopathic inflammatory myopathy and the risk of venous thromboembolism: a meta-analysis'. Together they form a unique fingerprint.

    Cite this