Idiopathic inflammatory myopathy and the risk of venous thromboembolism: a meta-analysis

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This study aimed at analyzing published data on the association between idiopathic inflammatory myopathy and venous thromboembolism (VTE). We examined studies on VTE risk in patients with polymyositis (PM) and/or dermatomyositis (DM), in the MEDLINE, EMBASE, and Cochrane databases and via manual searches. We performed a meta-analysis on the relative risks (RRs) of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in these patients. Five studies, including 8858 patients with PM/DM met the inclusion criteria. Meta-analysis revealed a significant association between PM/DM and VTE risk (RR = 4.364, 95% CI 2.128–8.949, p = 5.8 × 10−5). A significant association was found between PE risk and PM/DM (RR = 3.504, 95% CI 2.856–4.300, p < 1.0 × 10−8). Meta-analysis also indicated a significant association between DVT risk and PM/DM (RR = 7.481, 95% CI 3.355–16.68, p = 8.7 × 10−7). This meta-analysis demonstrated that both types of PM/DM are associated with an elevated risk of VTE, PE, and DVT, suggesting that patients with PM/DM should be carefully monitored for development of these conditions.

Original languageEnglish
Pages (from-to)1165-1173
Number of pages9
JournalRheumatology International
Volume37
Issue number7
DOIs
Publication statusPublished - 2017 Jul 1

Fingerprint

Myositis
Venous Thromboembolism
Dermatomyositis
Meta-Analysis
Pulmonary Embolism
Venous Thrombosis
MEDLINE
Databases

Keywords

  • Dermatomyositis
  • Polymyositis
  • Venous thromboembolism

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

Idiopathic inflammatory myopathy and the risk of venous thromboembolism : a meta-analysis. / Lee, Young Ho; Song, Gwan Gyu.

In: Rheumatology International, Vol. 37, No. 7, 01.07.2017, p. 1165-1173.

Research output: Contribution to journalArticle

@article{2a785989df2946d8890eb64041c3153e,
title = "Idiopathic inflammatory myopathy and the risk of venous thromboembolism: a meta-analysis",
abstract = "This study aimed at analyzing published data on the association between idiopathic inflammatory myopathy and venous thromboembolism (VTE). We examined studies on VTE risk in patients with polymyositis (PM) and/or dermatomyositis (DM), in the MEDLINE, EMBASE, and Cochrane databases and via manual searches. We performed a meta-analysis on the relative risks (RRs) of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in these patients. Five studies, including 8858 patients with PM/DM met the inclusion criteria. Meta-analysis revealed a significant association between PM/DM and VTE risk (RR = 4.364, 95{\%} CI 2.128–8.949, p = 5.8 × 10−5). A significant association was found between PE risk and PM/DM (RR = 3.504, 95{\%} CI 2.856–4.300, p < 1.0 × 10−8). Meta-analysis also indicated a significant association between DVT risk and PM/DM (RR = 7.481, 95{\%} CI 3.355–16.68, p = 8.7 × 10−7). This meta-analysis demonstrated that both types of PM/DM are associated with an elevated risk of VTE, PE, and DVT, suggesting that patients with PM/DM should be carefully monitored for development of these conditions.",
keywords = "Dermatomyositis, Polymyositis, Venous thromboembolism",
author = "Lee, {Young Ho} and Song, {Gwan Gyu}",
year = "2017",
month = "7",
day = "1",
doi = "10.1007/s00296-017-3735-0",
language = "English",
volume = "37",
pages = "1165--1173",
journal = "Rheumatology International",
issn = "0172-8172",
publisher = "Springer Verlag",
number = "7",

}

TY - JOUR

T1 - Idiopathic inflammatory myopathy and the risk of venous thromboembolism

T2 - a meta-analysis

AU - Lee, Young Ho

AU - Song, Gwan Gyu

PY - 2017/7/1

Y1 - 2017/7/1

N2 - This study aimed at analyzing published data on the association between idiopathic inflammatory myopathy and venous thromboembolism (VTE). We examined studies on VTE risk in patients with polymyositis (PM) and/or dermatomyositis (DM), in the MEDLINE, EMBASE, and Cochrane databases and via manual searches. We performed a meta-analysis on the relative risks (RRs) of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in these patients. Five studies, including 8858 patients with PM/DM met the inclusion criteria. Meta-analysis revealed a significant association between PM/DM and VTE risk (RR = 4.364, 95% CI 2.128–8.949, p = 5.8 × 10−5). A significant association was found between PE risk and PM/DM (RR = 3.504, 95% CI 2.856–4.300, p < 1.0 × 10−8). Meta-analysis also indicated a significant association between DVT risk and PM/DM (RR = 7.481, 95% CI 3.355–16.68, p = 8.7 × 10−7). This meta-analysis demonstrated that both types of PM/DM are associated with an elevated risk of VTE, PE, and DVT, suggesting that patients with PM/DM should be carefully monitored for development of these conditions.

AB - This study aimed at analyzing published data on the association between idiopathic inflammatory myopathy and venous thromboembolism (VTE). We examined studies on VTE risk in patients with polymyositis (PM) and/or dermatomyositis (DM), in the MEDLINE, EMBASE, and Cochrane databases and via manual searches. We performed a meta-analysis on the relative risks (RRs) of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in these patients. Five studies, including 8858 patients with PM/DM met the inclusion criteria. Meta-analysis revealed a significant association between PM/DM and VTE risk (RR = 4.364, 95% CI 2.128–8.949, p = 5.8 × 10−5). A significant association was found between PE risk and PM/DM (RR = 3.504, 95% CI 2.856–4.300, p < 1.0 × 10−8). Meta-analysis also indicated a significant association between DVT risk and PM/DM (RR = 7.481, 95% CI 3.355–16.68, p = 8.7 × 10−7). This meta-analysis demonstrated that both types of PM/DM are associated with an elevated risk of VTE, PE, and DVT, suggesting that patients with PM/DM should be carefully monitored for development of these conditions.

KW - Dermatomyositis

KW - Polymyositis

KW - Venous thromboembolism

UR - http://www.scopus.com/inward/record.url?scp=85019099941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019099941&partnerID=8YFLogxK

U2 - 10.1007/s00296-017-3735-0

DO - 10.1007/s00296-017-3735-0

M3 - Article

C2 - 28493173

AN - SCOPUS:85019099941

VL - 37

SP - 1165

EP - 1173

JO - Rheumatology International

JF - Rheumatology International

SN - 0172-8172

IS - 7

ER -