Abstract
This study aimed at analyzing published data on the association between idiopathic inflammatory myopathy and venous thromboembolism (VTE). We examined studies on VTE risk in patients with polymyositis (PM) and/or dermatomyositis (DM), in the MEDLINE, EMBASE, and Cochrane databases and via manual searches. We performed a meta-analysis on the relative risks (RRs) of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in these patients. Five studies, including 8858 patients with PM/DM met the inclusion criteria. Meta-analysis revealed a significant association between PM/DM and VTE risk (RR = 4.364, 95% CI 2.128–8.949, p = 5.8 × 10−5). A significant association was found between PE risk and PM/DM (RR = 3.504, 95% CI 2.856–4.300, p < 1.0 × 10−8). Meta-analysis also indicated a significant association between DVT risk and PM/DM (RR = 7.481, 95% CI 3.355–16.68, p = 8.7 × 10−7). This meta-analysis demonstrated that both types of PM/DM are associated with an elevated risk of VTE, PE, and DVT, suggesting that patients with PM/DM should be carefully monitored for development of these conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 1165-1173 |
| Number of pages | 9 |
| Journal | Rheumatology International |
| Volume | 37 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2017 Jul 1 |
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Keywords
- Dermatomyositis
- Polymyositis
- Venous thromboembolism
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology
Cite this
Idiopathic inflammatory myopathy and the risk of venous thromboembolism : a meta-analysis. / Lee, Young Ho; Song, Gwan Gyu.
In: Rheumatology International, Vol. 37, No. 7, 01.07.2017, p. 1165-1173.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Idiopathic inflammatory myopathy and the risk of venous thromboembolism
T2 - a meta-analysis
AU - Lee, Young Ho
AU - Song, Gwan Gyu
PY - 2017/7/1
Y1 - 2017/7/1
N2 - This study aimed at analyzing published data on the association between idiopathic inflammatory myopathy and venous thromboembolism (VTE). We examined studies on VTE risk in patients with polymyositis (PM) and/or dermatomyositis (DM), in the MEDLINE, EMBASE, and Cochrane databases and via manual searches. We performed a meta-analysis on the relative risks (RRs) of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in these patients. Five studies, including 8858 patients with PM/DM met the inclusion criteria. Meta-analysis revealed a significant association between PM/DM and VTE risk (RR = 4.364, 95% CI 2.128–8.949, p = 5.8 × 10−5). A significant association was found between PE risk and PM/DM (RR = 3.504, 95% CI 2.856–4.300, p < 1.0 × 10−8). Meta-analysis also indicated a significant association between DVT risk and PM/DM (RR = 7.481, 95% CI 3.355–16.68, p = 8.7 × 10−7). This meta-analysis demonstrated that both types of PM/DM are associated with an elevated risk of VTE, PE, and DVT, suggesting that patients with PM/DM should be carefully monitored for development of these conditions.
AB - This study aimed at analyzing published data on the association between idiopathic inflammatory myopathy and venous thromboembolism (VTE). We examined studies on VTE risk in patients with polymyositis (PM) and/or dermatomyositis (DM), in the MEDLINE, EMBASE, and Cochrane databases and via manual searches. We performed a meta-analysis on the relative risks (RRs) of VTE, pulmonary embolism (PE), and deep vein thrombosis (DVT) in these patients. Five studies, including 8858 patients with PM/DM met the inclusion criteria. Meta-analysis revealed a significant association between PM/DM and VTE risk (RR = 4.364, 95% CI 2.128–8.949, p = 5.8 × 10−5). A significant association was found between PE risk and PM/DM (RR = 3.504, 95% CI 2.856–4.300, p < 1.0 × 10−8). Meta-analysis also indicated a significant association between DVT risk and PM/DM (RR = 7.481, 95% CI 3.355–16.68, p = 8.7 × 10−7). This meta-analysis demonstrated that both types of PM/DM are associated with an elevated risk of VTE, PE, and DVT, suggesting that patients with PM/DM should be carefully monitored for development of these conditions.
KW - Dermatomyositis
KW - Polymyositis
KW - Venous thromboembolism
UR - http://www.scopus.com/inward/record.url?scp=85019099941&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019099941&partnerID=8YFLogxK
U2 - 10.1007/s00296-017-3735-0
DO - 10.1007/s00296-017-3735-0
M3 - Article
C2 - 28493173
AN - SCOPUS:85019099941
VL - 37
SP - 1165
EP - 1173
JO - Rheumatology International
JF - Rheumatology International
SN - 0172-8172
IS - 7
ER -