Idiopathic short stature phenotypes among Korean children: Cluster analysis

Research output: Contribution to journalArticle

Abstract

Idiopathic short stature (ISS) is a heterogeneous group and their responsiveness to growth hormone treatment varies among individuals. The aim of this study was to identify homogeneous phenotypes to better assess response before the initiation of treatment. We focused on person-centered approaches using a latent profile analysis. Clinical data of 218 children (127 boys and 91 girls) aged 4-15 years were obtained from the “LG Growth Study” which is a non-interventional Korean multicenter registry for growth hormone treatment. Growth hormone dose, first-year difference in height standard deviation score (Δheight SDS), mid-parental height SDS, and initial bone age were inputted into the model. The distribution of scatter plot was clearly distinguished at the chronological age of 8.83 years, Δheight SDS of 0.82 and mean GH dose of 0.36 mg/kg/week. The latent profile analysis revealed three distinct phenotypes names as follows: younger good responder (n = 56), older good responder (n = 111), and older poor responder (n = 51) groups. Despite more than twice the mean growth hormone dose, the older poor responder group showed the least improvement in the mean Δheight SDS. The pretreatment height velocity and peak growth hormone level were lower for the older poor responder group compared with those of the older good responder group. The statistically optimal cutoff point for predicting poor response was 3.41 cm/year for pretreatment height velocity and 9.18 ng/mL for peak growth hormone level. This study offers a new multidimensional approach to enable personalized growth hormone treatment optimization according to ISS phenotypes.

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalTohoku Journal of Experimental Medicine
Volume248
Issue number3
DOIs
Publication statusPublished - 2019 Jan 1

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Cluster analysis
Growth Hormone
Cluster Analysis
Phenotype
Therapeutics
Names
Registries
Bone
Bone and Bones
Growth

Keywords

  • Children
  • Cluster analysis
  • Growth hormone
  • Idiopathic short stature
  • Phenotype

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Idiopathic short stature phenotypes among Korean children : Cluster analysis. / Nam, Hyo Kyoung; Kim, Hye Ryun; Lee, Kee Hyoung; Rhie, Young Jun.

In: Tohoku Journal of Experimental Medicine, Vol. 248, No. 3, 01.01.2019, p. 193-200.

Research output: Contribution to journalArticle

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