IgG4-related inflammatory pseudotumor of the lung, a pulmonary manifestation of the IgG4-related sclerosing disease

Younghye Kim, Hoiseon Jeong, Aeree Kim, Han Kyeom Kim, Bong Kyung Shin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report a case of IgG4-related inflammatory pseudotumor of lung, which coexisted with autoimmune pancreatitis. A 65-year-old man was admitted with left lung mass and left upper abdominal pain. A biopsy was performed for the lung mass under suspicion of malignancy. Microscopic examination demonstrated the proliferation of spindle cells, fibrosis and heavy infiltration of plasma cells, which were strongly immunoreactive for IgG4. Diffusely enlarged pancreas in abdominal computed tomography scan and elevated serum IgG4 level suggested the patient also had an autoimmune pancreatitis. We concluded this patient had the pulmonary inflammatory pseudotumor, as well as the autoimmune pancreatitis. These features were manifestations of the so-called IgG4-related sclerosing disease, which is a recently proposed clinicopathological entity, characterized by extensive IgG4-positive plasma cell infiltration and sclerosing inflammation in various organs.

Original languageEnglish
Pages (from-to)14-17
Number of pages4
JournalBasic and Applied Pathology
Volume4
Issue number1
DOIs
Publication statusPublished - 2011 Mar

Keywords

  • Autoimmune pancreatitis
  • Immunoglobulin g
  • Lung
  • Plasma cell granuloma
  • Pulmonary

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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