Abstract
We report a case of IgG4-related inflammatory pseudotumor of lung, which coexisted with autoimmune pancreatitis. A 65-year-old man was admitted with left lung mass and left upper abdominal pain. A biopsy was performed for the lung mass under suspicion of malignancy. Microscopic examination demonstrated the proliferation of spindle cells, fibrosis and heavy infiltration of plasma cells, which were strongly immunoreactive for IgG4. Diffusely enlarged pancreas in abdominal computed tomography scan and elevated serum IgG4 level suggested the patient also had an autoimmune pancreatitis. We concluded this patient had the pulmonary inflammatory pseudotumor, as well as the autoimmune pancreatitis. These features were manifestations of the so-called IgG4-related sclerosing disease, which is a recently proposed clinicopathological entity, characterized by extensive IgG4-positive plasma cell infiltration and sclerosing inflammation in various organs.
| Original language | English |
|---|---|
| Pages (from-to) | 14-17 |
| Number of pages | 4 |
| Journal | Basic and Applied Pathology |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2011 Mar 1 |
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Keywords
- Autoimmune pancreatitis
- Immunoglobulin g
- Lung
- Plasma cell granuloma
- Pulmonary
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medicine(all)
Cite this
IgG4-related inflammatory pseudotumor of the lung, a pulmonary manifestation of the IgG4-related sclerosing disease. / Kim, Younghye; Jeong, Hoiseon; Kim, Aeree; Kim, Han Kyeom; Shin, Bong Kyung.
In: Basic and Applied Pathology, Vol. 4, No. 1, 01.03.2011, p. 14-17.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - IgG4-related inflammatory pseudotumor of the lung, a pulmonary manifestation of the IgG4-related sclerosing disease
AU - Kim, Younghye
AU - Jeong, Hoiseon
AU - Kim, Aeree
AU - Kim, Han Kyeom
AU - Shin, Bong Kyung
PY - 2011/3/1
Y1 - 2011/3/1
N2 - We report a case of IgG4-related inflammatory pseudotumor of lung, which coexisted with autoimmune pancreatitis. A 65-year-old man was admitted with left lung mass and left upper abdominal pain. A biopsy was performed for the lung mass under suspicion of malignancy. Microscopic examination demonstrated the proliferation of spindle cells, fibrosis and heavy infiltration of plasma cells, which were strongly immunoreactive for IgG4. Diffusely enlarged pancreas in abdominal computed tomography scan and elevated serum IgG4 level suggested the patient also had an autoimmune pancreatitis. We concluded this patient had the pulmonary inflammatory pseudotumor, as well as the autoimmune pancreatitis. These features were manifestations of the so-called IgG4-related sclerosing disease, which is a recently proposed clinicopathological entity, characterized by extensive IgG4-positive plasma cell infiltration and sclerosing inflammation in various organs.
AB - We report a case of IgG4-related inflammatory pseudotumor of lung, which coexisted with autoimmune pancreatitis. A 65-year-old man was admitted with left lung mass and left upper abdominal pain. A biopsy was performed for the lung mass under suspicion of malignancy. Microscopic examination demonstrated the proliferation of spindle cells, fibrosis and heavy infiltration of plasma cells, which were strongly immunoreactive for IgG4. Diffusely enlarged pancreas in abdominal computed tomography scan and elevated serum IgG4 level suggested the patient also had an autoimmune pancreatitis. We concluded this patient had the pulmonary inflammatory pseudotumor, as well as the autoimmune pancreatitis. These features were manifestations of the so-called IgG4-related sclerosing disease, which is a recently proposed clinicopathological entity, characterized by extensive IgG4-positive plasma cell infiltration and sclerosing inflammation in various organs.
KW - Autoimmune pancreatitis
KW - Immunoglobulin g
KW - Lung
KW - Plasma cell granuloma
KW - Pulmonary
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U2 - 10.1111/j.1755-9294.2011.01098.x
DO - 10.1111/j.1755-9294.2011.01098.x
M3 - Article
VL - 4
SP - 14
EP - 17
JO - Basic and Applied Pathology
JF - Basic and Applied Pathology
SN - 1755-9294
IS - 1
ER -