IL-17A promotes transdifferentiation of mouse myoblast cells (C2C12) into adipocytes by increasing the expression of peroxisome proliferator-activated receptor γ through CAAT/enhancer binding protein β signaling

Suk Jun Lee, Eun Ju Lee, Sang Hoon Kim, Inho Choi, Dong Mok Lee, Hyun Jeong Lee, Duhak Yoon, Taehoon Chun

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose of work: Helper 17 T (Th17) effector cells are a recently identified Th subset and possess a unique property that distinguishes them from Th1 and Th2 subsets. The functional role of Th17 effector cells involves inflammatory responses, including autoimmunity and infection of specific pathogens. Therefore, IL-17A and its receptors may play a key role in determining the progression of certain inflammatory reactions. However, the relationship between IL-17A and adipogenesis has not yet been examined. Therefore, in this study, the effect of IL-17A on the adipogenic transdifferentiation of mouse myoblast (C2C12) cells was examined. CAAT/enhancer binding-protein β (C/EPBβ) signaling through the IL-17A receptor promoted adipogenic transdifferentiation of myoblast cells by activating peroxisome proliferator-activated receptor γ (PPARγ). These results will advance our understanding of the physiological function of IL-17A in myoblasts during inflammation, as well as the relationship between adipogenesis and inflammation.

Original languageEnglish
Pages (from-to)229-235
Number of pages7
JournalBiotechnology letters
Volume33
Issue number2
DOIs
Publication statusPublished - 2011 Feb

Keywords

  • Adipocyte
  • IL-17A
  • Inflammation
  • Myoblast
  • Transdifferentiation

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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