IL-18 and cutaneous inflammatory diseases

Ji Hyun Lee, Dae Ho Cho, Hyun Jeong Park

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities.

Original languageEnglish
Pages (from-to)29357-29369
Number of pages13
JournalInternational journal of molecular sciences
Volume16
Issue number12
DOIs
Publication statusPublished - 2015 Dec 9
Externally publishedYes

Fingerprint

interleukins
Interleukin-18
Skin Diseases
Skin
Interferons
interferon
pathogenesis
Interleukin-1
regulators
Cytokines

Keywords

  • Alopecia areata
  • Atopic dermatitis
  • Contact dermatitis
  • Drug eruption
  • Fibrosis
  • Graft-versus-host disease
  • IL-18
  • Lupus erythematosus
  • Psoriasis
  • Skin disease
  • Skin tumor
  • Urticaria

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

IL-18 and cutaneous inflammatory diseases. / Lee, Ji Hyun; Cho, Dae Ho; Park, Hyun Jeong.

In: International journal of molecular sciences, Vol. 16, No. 12, 09.12.2015, p. 29357-29369.

Research output: Contribution to journalReview article

Lee, Ji Hyun ; Cho, Dae Ho ; Park, Hyun Jeong. / IL-18 and cutaneous inflammatory diseases. In: International journal of molecular sciences. 2015 ; Vol. 16, No. 12. pp. 29357-29369.
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