IL-18 and cutaneous inflammatory diseases

Ji Hyun Lee, Dae Ho Cho, Hyun Jeong Park

Research output: Contribution to journalReview articlepeer-review

55 Citations (Scopus)


Interleukin (IL)-18, an IL-1 family cytokine, is a pleiotropic immune regulator. IL-18 plays a strong proinflammatory role by inducing interferon (IFN)-γ. Previous studies have implicated IL-18 in the pathogenesis of various diseases. However, it is not well understood biologic activities of IL-18 in the diverse skin diseases. Here, we have reviewed the expression and function of IL-18 in skin diseases including inflammatory diseases. This article provides an evidence-based understanding of the role of IL-18 in skin diseases and its relationship with disease activities.

Original languageEnglish
Pages (from-to)29357-29369
Number of pages13
JournalInternational journal of molecular sciences
Issue number12
Publication statusPublished - 2015 Dec 9
Externally publishedYes


  • Alopecia areata
  • Atopic dermatitis
  • Contact dermatitis
  • Drug eruption
  • Fibrosis
  • Graft-versus-host disease
  • IL-18
  • Lupus erythematosus
  • Psoriasis
  • Skin disease
  • Skin tumor
  • Urticaria

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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