IL-18 downregulates collagen production in human dermal fibroblasts via the ERK pathway

Medicine & Life Sciences

• Interleukin-18 100%
• Extracellular Signal-Regulated MAP Kinases 92%
• Collagen 64%
• Fibroblasts 63%
• Down-Regulation 59%
• Skin 46%
• Inflammation Mediators 10%
• Collagen Type III 10%
• Gene Expression 10%
• 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 10%
• Mitogen-Activated Protein Kinase 3 9%
• Systemic Scleroderma 9%
• Transforming Growth Factors 8%
• Collagen Type I 8%
• Small Interfering RNA 7%
• Phosphorylation 5%
• Cytokines 5%

Chemical Compounds

• Collagen 80%
• Antifibrotic 20%
• Small Interfering RNA 16%
• Phosphotransferase Inhibitor 15%
• Reduction 5%