"Illusionary" Polymerase activity triggered by metal ions: Use for molecular logic-gate operations

Ki Soo Park, Cheulhee Jung, Hyun Gyu Park

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Metal ion, an astonishing illusionist: In a new concept, "illusionary" polymerase activity is intentionally triggered at T-T and C-C mismatched primers by Hg2+ and Ag+ ions, respectively. A novel strategy to construct molecular-scale logic gates utilizes the nonnatural polymerase activity induced by the metal ions by rational design of the primers and selection of the type of DNA polymerase (see picture).

Original languageEnglish
Pages (from-to)9757-9760
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number50
DOIs
Publication statusPublished - 2010 Dec 10
Externally publishedYes

Keywords

  • DNA
  • mercury
  • molecular logic gates
  • nucleotides
  • silver

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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