IM-MS for Supramolecular Systems: Structures and Dynamics of Noncovalent Complexes From Solution to Gas Phase

Tae Su Choi, Jongcheol Seo, Hugh I. Kim

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Ion mobility mass spectrometry (IM-MS) has been broadly utilized in the structural characterization of noncovalent, supramolecular complexes. In this chapter, we discuss three types of supramolecular complexes, and their structural dynamics observed in IM-MS studies. Firstly, host–guest chemistry of cucurbituril, crown ether, and cyclodextrin is discussed. Secondly, self-assembly mechanisms of amino acids and peptides are introduced. Finally, structural studies of protein–protein complexes are presented. We mainly focus on insights into the physicochemical properties of supramolecular complexes (e.g. molecular interactions, role of water molecules in complexation and structural features).

Original languageEnglish
Title of host publicationComprehensive Analytical Chemistry
PublisherElsevier B.V.
Pages197-236
Number of pages40
DOIs
Publication statusPublished - 2019 Jan 1

Publication series

NameComprehensive Analytical Chemistry
Volume83
ISSN (Print)0166-526X

Keywords

  • Host–guest chemistry
  • Ion mobility mass spectrometry
  • Protein–protein complex
  • Self-assembly

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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    Choi, T. S., Seo, J., & Kim, H. I. (2019). IM-MS for Supramolecular Systems: Structures and Dynamics of Noncovalent Complexes From Solution to Gas Phase. In Comprehensive Analytical Chemistry (pp. 197-236). (Comprehensive Analytical Chemistry; Vol. 83). Elsevier B.V.. https://doi.org/10.1016/bs.coac.2018.09.002