Abstract
Currently, there does not exist reliable MV treatment or protocols in critical care to treat acute respiratory diseases, and thus no proven way to optimise care to minimise the mortality, length of stay or cost. The overall approach of this research is to improve protocols by using appropriate computer models that take into account the essential lung mechanics. The aim of this research is to create an automated algorithm for tracking the boundary of individual or groups of alveoli, and to convert this into a pressure volume curve for three different types of alveoli. A technique called in vivo microscopy has been developed by Schiller et al which visualizes the inflation and deflation of individual alveoli in a surfactant deactivation model of lung injury in pigs. Three different types of alveoli were tracked using data from Schiller et al, type I, II and III. These types correspond to healthy alveoli, non-collapsing but partially diseased alveoli, and fully collapsing diseased alveoli respectively. The boundaries of all the alveoli that were tracked, compared well visually to the movies. Pressure versus Area curves were derived for both inflation and deflation, they captured the expected physiological behaviour, and were qualitatively similar to the quasi-static pressure area curves derived in Schiller et al, Quantitative differences are due to the dynamic effects of ventilation which were not investigated in Schiller et al.
| Original language | English |
|---|---|
| Title of host publication | 15th International Conference on Mechatronics and Machine Vision in Practice, M2VIP'08 |
| Pages | 5-10 |
| Number of pages | 6 |
| DOIs | |
| Publication status | Published - 2008 Dec 1 |
| Externally published | Yes |
| Event | 15th International Conference on Mechatronics and Machine Vision in Practice, M2VIP'08 - Auckland, New Zealand Duration: 2008 Dec 2 → 2008 Dec 4 |
Other
| Other | 15th International Conference on Mechatronics and Machine Vision in Practice, M2VIP'08 |
|---|---|
| Country | New Zealand |
| City | Auckland |
| Period | 08/12/2 → 08/12/4 |
Fingerprint
ASJC Scopus subject areas
- Computer Vision and Pattern Recognition
- Control and Systems Engineering
- Electrical and Electronic Engineering
- Mechanical Engineering
Cite this
Image-based measurement of alveoli volume expansion in an animal model of a diseased lung. / Hann, C. E.; Hewett, D.; Chase, J. G.; Rabczuk, Timon; Sundaresan, A.; Chen, X.; Wang, W.; Shaw, G. M.
15th International Conference on Mechatronics and Machine Vision in Practice, M2VIP'08. 2008. p. 5-10 4749498.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Image-based measurement of alveoli volume expansion in an animal model of a diseased lung
AU - Hann, C. E.
AU - Hewett, D.
AU - Chase, J. G.
AU - Rabczuk, Timon
AU - Sundaresan, A.
AU - Chen, X.
AU - Wang, W.
AU - Shaw, G. M.
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Currently, there does not exist reliable MV treatment or protocols in critical care to treat acute respiratory diseases, and thus no proven way to optimise care to minimise the mortality, length of stay or cost. The overall approach of this research is to improve protocols by using appropriate computer models that take into account the essential lung mechanics. The aim of this research is to create an automated algorithm for tracking the boundary of individual or groups of alveoli, and to convert this into a pressure volume curve for three different types of alveoli. A technique called in vivo microscopy has been developed by Schiller et al which visualizes the inflation and deflation of individual alveoli in a surfactant deactivation model of lung injury in pigs. Three different types of alveoli were tracked using data from Schiller et al, type I, II and III. These types correspond to healthy alveoli, non-collapsing but partially diseased alveoli, and fully collapsing diseased alveoli respectively. The boundaries of all the alveoli that were tracked, compared well visually to the movies. Pressure versus Area curves were derived for both inflation and deflation, they captured the expected physiological behaviour, and were qualitatively similar to the quasi-static pressure area curves derived in Schiller et al, Quantitative differences are due to the dynamic effects of ventilation which were not investigated in Schiller et al.
AB - Currently, there does not exist reliable MV treatment or protocols in critical care to treat acute respiratory diseases, and thus no proven way to optimise care to minimise the mortality, length of stay or cost. The overall approach of this research is to improve protocols by using appropriate computer models that take into account the essential lung mechanics. The aim of this research is to create an automated algorithm for tracking the boundary of individual or groups of alveoli, and to convert this into a pressure volume curve for three different types of alveoli. A technique called in vivo microscopy has been developed by Schiller et al which visualizes the inflation and deflation of individual alveoli in a surfactant deactivation model of lung injury in pigs. Three different types of alveoli were tracked using data from Schiller et al, type I, II and III. These types correspond to healthy alveoli, non-collapsing but partially diseased alveoli, and fully collapsing diseased alveoli respectively. The boundaries of all the alveoli that were tracked, compared well visually to the movies. Pressure versus Area curves were derived for both inflation and deflation, they captured the expected physiological behaviour, and were qualitatively similar to the quasi-static pressure area curves derived in Schiller et al, Quantitative differences are due to the dynamic effects of ventilation which were not investigated in Schiller et al.
UR - http://www.scopus.com/inward/record.url?scp=61949436790&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=61949436790&partnerID=8YFLogxK
U2 - 10.1109/MMVIP.2008.4749498
DO - 10.1109/MMVIP.2008.4749498
M3 - Conference contribution
SN - 9780473135324
SP - 5
EP - 10
BT - 15th International Conference on Mechatronics and Machine Vision in Practice, M2VIP'08
ER -