Imaging deep within a scattering medium using collective accumulation of single-scattered waves

Sungsam Kang, Seungwon Jeong, Wonjun Choi, Hakseok Ko, Taeseok D. Yang, Jang Ho Joo, Jae-Seung Lee, Yong Sik Lim, Q Han Park, Wonshik Choi

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Optical microscopy suffers from a loss of resolving power when imaging targets are embedded in thick scattering media because of the dominance of strong multiple-scattered waves over waves scattered only a single time by the targets. Here, we present an approach that maintains full optical resolution when imaging deep within scattering media. We use both time-gated detection and spatial input-output correlation to identify those reflected waves that conserve in-plane momentum, which is a property of single-scattered waves. By implementing a superradiance-like collective accumulation of the single-scattered waves, we enhance the ratio of the single scattering signal to the multiple scattering background by more than three orders of magnitude. An imaging depth of 11.5 times the scattering mean free path is achieved with a near-diffraction-limited resolution of 1.5 μm. Our method of distinguishing single- from multiple-scattered waves will open new routes to deep-tissue imaging and studying the physics of the interaction of light with complex media.

Original languageEnglish
Pages (from-to)253-258
Number of pages6
JournalNature Photonics
Volume9
Issue number4
DOIs
Publication statusPublished - 2015 Mar 31

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Scattering
Imaging techniques
scattering
Superradiance
reflected waves
mean free path
Multiple scattering
Optical resolving power
Optical microscopy
routes
Momentum
microscopy
momentum
Physics
Diffraction
physics
Tissue
output
diffraction
interactions

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Imaging deep within a scattering medium using collective accumulation of single-scattered waves. / Kang, Sungsam; Jeong, Seungwon; Choi, Wonjun; Ko, Hakseok; Yang, Taeseok D.; Joo, Jang Ho; Lee, Jae-Seung; Lim, Yong Sik; Park, Q Han; Choi, Wonshik.

In: Nature Photonics, Vol. 9, No. 4, 31.03.2015, p. 253-258.

Research output: Contribution to journalArticle

Kang, Sungsam ; Jeong, Seungwon ; Choi, Wonjun ; Ko, Hakseok ; Yang, Taeseok D. ; Joo, Jang Ho ; Lee, Jae-Seung ; Lim, Yong Sik ; Park, Q Han ; Choi, Wonshik. / Imaging deep within a scattering medium using collective accumulation of single-scattered waves. In: Nature Photonics. 2015 ; Vol. 9, No. 4. pp. 253-258.
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