Imaging features of growing teratoma syndrome following a malignant ovarian germ cell tumor

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7 Citations (Scopus)

Abstract

OBJECTIVE: To access imaging findings of growing teratoma syndrome (GTS), which is a rare complication of malignant ovarian germ cell tumor (GCT) after chemotherapy. METHODS: Five patients met the criteria for GTS. Computed tomography and magnetic resonance images were retrospectively reviewed by 2 radiologists in consensus for margin, attenuation, and the presence of gross fat or calcification of GTS lesions, which were compared with primary GCTs regarding tumor composition. RESULTS: Growing teratoma syndrome lesions were characterized as follows: poorly circumscribed, diffuse peritoneal masses in 2 patients; well-circumscribed, localized peritoneal masses in 1 patient, and ovarian masses in 2 patients. Features more noticeable in GTS lesions were more prominent fatty components in 4 patients and purely cystic lesion in 1 patient. CONCLUSIONS: Growing teratoma syndrome can be manifested as intraperitoneal masses with an increased fatty or cystic component. Radiologists should consider GTS when there are such masses on follow-up imaging studies in patients with malignant ovarian GCT.

Original languageEnglish
Pages (from-to)551-557
Number of pages7
JournalJournal of Computer Assisted Tomography
Volume38
Issue number4
DOIs
Publication statusPublished - 2014 Jan 1

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Germ Cell and Embryonal Neoplasms
Teratoma
Magnetic Resonance Spectroscopy
Fats
Tomography
Drug Therapy
Neoplasms

Keywords

  • adjuvant chemotherapy
  • germ cell tumors
  • multidetector computed tomography
  • neoplastic processes
  • ovarian neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Imaging features of growing teratoma syndrome following a malignant ovarian germ cell tumor",
abstract = "OBJECTIVE: To access imaging findings of growing teratoma syndrome (GTS), which is a rare complication of malignant ovarian germ cell tumor (GCT) after chemotherapy. METHODS: Five patients met the criteria for GTS. Computed tomography and magnetic resonance images were retrospectively reviewed by 2 radiologists in consensus for margin, attenuation, and the presence of gross fat or calcification of GTS lesions, which were compared with primary GCTs regarding tumor composition. RESULTS: Growing teratoma syndrome lesions were characterized as follows: poorly circumscribed, diffuse peritoneal masses in 2 patients; well-circumscribed, localized peritoneal masses in 1 patient, and ovarian masses in 2 patients. Features more noticeable in GTS lesions were more prominent fatty components in 4 patients and purely cystic lesion in 1 patient. CONCLUSIONS: Growing teratoma syndrome can be manifested as intraperitoneal masses with an increased fatty or cystic component. Radiologists should consider GTS when there are such masses on follow-up imaging studies in patients with malignant ovarian GCT.",
keywords = "adjuvant chemotherapy, germ cell tumors, multidetector computed tomography, neoplastic processes, ovarian neoplasms",
author = "Han, {Na Yeon} and Sung, {Deuk Jae} and Beomjin Park and Kim, {Min Ju} and Cho, {Sung Bum} and Kim, {Kyeong Ah} and Song, {Jae Yun}",
year = "2014",
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doi = "10.1097/RCT.0000000000000073",
language = "English",
volume = "38",
pages = "551--557",
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T1 - Imaging features of growing teratoma syndrome following a malignant ovarian germ cell tumor

AU - Han, Na Yeon

AU - Sung, Deuk Jae

AU - Park, Beomjin

AU - Kim, Min Ju

AU - Cho, Sung Bum

AU - Kim, Kyeong Ah

AU - Song, Jae Yun

PY - 2014/1/1

Y1 - 2014/1/1

N2 - OBJECTIVE: To access imaging findings of growing teratoma syndrome (GTS), which is a rare complication of malignant ovarian germ cell tumor (GCT) after chemotherapy. METHODS: Five patients met the criteria for GTS. Computed tomography and magnetic resonance images were retrospectively reviewed by 2 radiologists in consensus for margin, attenuation, and the presence of gross fat or calcification of GTS lesions, which were compared with primary GCTs regarding tumor composition. RESULTS: Growing teratoma syndrome lesions were characterized as follows: poorly circumscribed, diffuse peritoneal masses in 2 patients; well-circumscribed, localized peritoneal masses in 1 patient, and ovarian masses in 2 patients. Features more noticeable in GTS lesions were more prominent fatty components in 4 patients and purely cystic lesion in 1 patient. CONCLUSIONS: Growing teratoma syndrome can be manifested as intraperitoneal masses with an increased fatty or cystic component. Radiologists should consider GTS when there are such masses on follow-up imaging studies in patients with malignant ovarian GCT.

AB - OBJECTIVE: To access imaging findings of growing teratoma syndrome (GTS), which is a rare complication of malignant ovarian germ cell tumor (GCT) after chemotherapy. METHODS: Five patients met the criteria for GTS. Computed tomography and magnetic resonance images were retrospectively reviewed by 2 radiologists in consensus for margin, attenuation, and the presence of gross fat or calcification of GTS lesions, which were compared with primary GCTs regarding tumor composition. RESULTS: Growing teratoma syndrome lesions were characterized as follows: poorly circumscribed, diffuse peritoneal masses in 2 patients; well-circumscribed, localized peritoneal masses in 1 patient, and ovarian masses in 2 patients. Features more noticeable in GTS lesions were more prominent fatty components in 4 patients and purely cystic lesion in 1 patient. CONCLUSIONS: Growing teratoma syndrome can be manifested as intraperitoneal masses with an increased fatty or cystic component. Radiologists should consider GTS when there are such masses on follow-up imaging studies in patients with malignant ovarian GCT.

KW - adjuvant chemotherapy

KW - germ cell tumors

KW - multidetector computed tomography

KW - neoplastic processes

KW - ovarian neoplasms

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