Imaging features of growing teratoma syndrome following a malignant ovarian germ cell tumor

Na Yeon Han, Deuk Jae Sung, Beom Jin Park, Min Ju Kim, Sung Bum Cho, Kyeong Ah Kim, Jae Yun Song

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)


    OBJECTIVE: To access imaging findings of growing teratoma syndrome (GTS), which is a rare complication of malignant ovarian germ cell tumor (GCT) after chemotherapy. METHODS: Five patients met the criteria for GTS. Computed tomography and magnetic resonance images were retrospectively reviewed by 2 radiologists in consensus for margin, attenuation, and the presence of gross fat or calcification of GTS lesions, which were compared with primary GCTs regarding tumor composition. RESULTS: Growing teratoma syndrome lesions were characterized as follows: poorly circumscribed, diffuse peritoneal masses in 2 patients; well-circumscribed, localized peritoneal masses in 1 patient, and ovarian masses in 2 patients. Features more noticeable in GTS lesions were more prominent fatty components in 4 patients and purely cystic lesion in 1 patient. CONCLUSIONS: Growing teratoma syndrome can be manifested as intraperitoneal masses with an increased fatty or cystic component. Radiologists should consider GTS when there are such masses on follow-up imaging studies in patients with malignant ovarian GCT.

    Original languageEnglish
    Pages (from-to)551-557
    Number of pages7
    JournalJournal of Computer Assisted Tomography
    Issue number4
    Publication statusPublished - 2014


    • adjuvant chemotherapy
    • germ cell tumors
    • multidetector computed tomography
    • neoplastic processes
    • ovarian neoplasms

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging


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