Immediate early response of the p62 gene encoding a non-proteasomal multiubiquitin chain binding protein

Young Han Lee, Jesang Ko, Insil Joung, Jung Hye Kim, Jaekyoon Shin

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

p62 is a cytoplasmic ubiquitin chain binding protein. Upon a variety of extracellular signals, both transcript and protein levels of p62 were rapidly increased. These signals include phorbol 12-myristate 13-acetate (PMA) and calcium ionomycin for peripheral blood mononuclear cells, serum or PDGF for serum-starved NIH3T3 cells, IL-3 for the G1 arrested pre-B cell line Ba/F3, and PMA for a human promyelocyte line U937. The elevation of p62 transcript level is due to temporal stabilization of mRNA and rapid activation of the p62 gene. Cycloheximide-induced enhanced transcription suggests the immediate early response of the p62 gene. The rapid induction of p62 indicates the presence of a novel ubiquitination-mediated regulatory mechanism during cell proliferation and differentiation. Copyright (C) 1998 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)297-300
Number of pages4
JournalFEBS Letters
Volume438
Issue number3
DOIs
Publication statusPublished - 1998 Nov 6
Externally publishedYes

Keywords

  • Immediate early response
  • Ubiquitin
  • p62

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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