Immobilization-free screening of aptamers assisted by graphene oxide

Jee Woong Park; Rameshwar Tatavarty; Dae Woo Kim; Hee Tae Jung; Man Bock Gu

doi:10.1039/c2cc16473f

Immobilization-free screening of aptamers assisted by graphene oxide

Jee Woong Park, Rameshwar Tatavarty, Dae Woo Kim, Hee Tae Jung, Man Bock Gu

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

141 Citations (Scopus)

Abstract

Graphene oxide (GO) has the ability to separate free short ssDNA in heterogeneous solution. This feature is applied as a label free platform for screening of aptamers that bind to their target with high affinity and specificity. Herein, we report an aptamer selection strategy for Nampt protein based on GO.

Original language	English
Pages (from-to)	2071-2073
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	15
DOIs	https://doi.org/10.1039/c2cc16473f
Publication status	Published - 2012 Jan 24

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc16473f

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abstract = "Graphene oxide (GO) has the ability to separate free short ssDNA in heterogeneous solution. This feature is applied as a label free platform for screening of aptamers that bind to their target with high affinity and specificity. Herein, we report an aptamer selection strategy for Nampt protein based on GO.",

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AU - Tatavarty, Rameshwar

AU - Kim, Dae Woo

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AU - Gu, Man Bock

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AB - Graphene oxide (GO) has the ability to separate free short ssDNA in heterogeneous solution. This feature is applied as a label free platform for screening of aptamers that bind to their target with high affinity and specificity. Herein, we report an aptamer selection strategy for Nampt protein based on GO.

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Immobilization-free screening of aptamers assisted by graphene oxide

Abstract

ASJC Scopus subject areas

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