Immobilization of poly(ethylene glycol) or its sulfonate onto polymer surfaces by ozone oxidation

Young Gun Ko, Young Ha Kim, Ki Dong Park, Hee Jung Lee, Won Kyu Lee, Hyung Dal Park, Soo Hyun Kim, Gil Sun Lee, Dong June Ahn

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

A novel surface modification method has been developed to improve biocompatibility of polymeric biomaterials. This approach involves ozonation and then followed by graft polymerization with acrylates containing PEG, sulfonated PEG or by coupling of PEG derivatives. All the reactions were confirmed by ATR FT-IR and ESCA. The degree of ozonation measured by the iodide method was dependent on the ozone permeability of the polymers used. Surface hydrophilicity was investigated by measuring the contact angles. Ozonation itself yielded a slight increase in hydrophilicity and a decrease in platelet adhesion, but PEG immobilization showed a significant effect on surface hydrophilicity and platelet adhesion to confirm well-known PEG's passivity which minimize the adhesion of blood components on polymer surfaces. Both graft polymerization and coupling were effective for PU. In contrast, only grafting gave enough yields for PMMA and silicone. Platelet adhesion results demonstrated that all PEG modified surfaces adsorbed lower platelet adhesion than untreated or ozonated ones. Polymers coupled with sulfonated PEG exhibited the lowest platelet adhesion when compared with control and PEG coupled ones by virtue of the synergistic effect of non-adhesive PEG and negatively charged SO3 groups. This PEG or sulfonated PEG immobilization technology using ozonation is relatively simple for introducing uniform surface modification and therefore very useful for practical application of blood contacting medical devices.

Original languageEnglish
Pages (from-to)2115-2123
Number of pages9
JournalBiomaterials
Volume22
Issue number15
DOIs
Publication statusPublished - 2001 Aug 1

Fingerprint

Ethylene Glycol
Ozone
Immobilization
Polyethylene glycols
Polymers
Blood Platelets
Oxidation
Hydrophobic and Hydrophilic Interactions
Platelets
Ozonization
Adhesion
Polymerization
Hydrophilicity
Acrylates
Transplants
Biocompatible Materials
Iodides
Polymethyl Methacrylate
Silicones
Grafts

Keywords

  • Ozone treatment
  • PEG/PEG-SO immobilization
  • Platelet adhesion
  • Wettability

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Immobilization of poly(ethylene glycol) or its sulfonate onto polymer surfaces by ozone oxidation. / Ko, Young Gun; Kim, Young Ha; Park, Ki Dong; Lee, Hee Jung; Lee, Won Kyu; Park, Hyung Dal; Kim, Soo Hyun; Lee, Gil Sun; Ahn, Dong June.

In: Biomaterials, Vol. 22, No. 15, 01.08.2001, p. 2115-2123.

Research output: Contribution to journalArticle

Ko, YG, Kim, YH, Park, KD, Lee, HJ, Lee, WK, Park, HD, Kim, SH, Lee, GS & Ahn, DJ 2001, 'Immobilization of poly(ethylene glycol) or its sulfonate onto polymer surfaces by ozone oxidation', Biomaterials, vol. 22, no. 15, pp. 2115-2123. https://doi.org/10.1016/S0142-9612(00)00400-2
Ko, Young Gun ; Kim, Young Ha ; Park, Ki Dong ; Lee, Hee Jung ; Lee, Won Kyu ; Park, Hyung Dal ; Kim, Soo Hyun ; Lee, Gil Sun ; Ahn, Dong June. / Immobilization of poly(ethylene glycol) or its sulfonate onto polymer surfaces by ozone oxidation. In: Biomaterials. 2001 ; Vol. 22, No. 15. pp. 2115-2123.
@article{805da0c783b74f7c931bc55ff157ee1d,
title = "Immobilization of poly(ethylene glycol) or its sulfonate onto polymer surfaces by ozone oxidation",
abstract = "A novel surface modification method has been developed to improve biocompatibility of polymeric biomaterials. This approach involves ozonation and then followed by graft polymerization with acrylates containing PEG, sulfonated PEG or by coupling of PEG derivatives. All the reactions were confirmed by ATR FT-IR and ESCA. The degree of ozonation measured by the iodide method was dependent on the ozone permeability of the polymers used. Surface hydrophilicity was investigated by measuring the contact angles. Ozonation itself yielded a slight increase in hydrophilicity and a decrease in platelet adhesion, but PEG immobilization showed a significant effect on surface hydrophilicity and platelet adhesion to confirm well-known PEG's passivity which minimize the adhesion of blood components on polymer surfaces. Both graft polymerization and coupling were effective for PU. In contrast, only grafting gave enough yields for PMMA and silicone. Platelet adhesion results demonstrated that all PEG modified surfaces adsorbed lower platelet adhesion than untreated or ozonated ones. Polymers coupled with sulfonated PEG exhibited the lowest platelet adhesion when compared with control and PEG coupled ones by virtue of the synergistic effect of non-adhesive PEG and negatively charged SO3 groups. This PEG or sulfonated PEG immobilization technology using ozonation is relatively simple for introducing uniform surface modification and therefore very useful for practical application of blood contacting medical devices.",
keywords = "Ozone treatment, PEG/PEG-SO immobilization, Platelet adhesion, Wettability",
author = "Ko, {Young Gun} and Kim, {Young Ha} and Park, {Ki Dong} and Lee, {Hee Jung} and Lee, {Won Kyu} and Park, {Hyung Dal} and Kim, {Soo Hyun} and Lee, {Gil Sun} and Ahn, {Dong June}",
year = "2001",
month = "8",
day = "1",
doi = "10.1016/S0142-9612(00)00400-2",
language = "English",
volume = "22",
pages = "2115--2123",
journal = "Biomaterials",
issn = "0142-9612",
publisher = "Elsevier BV",
number = "15",

}

TY - JOUR

T1 - Immobilization of poly(ethylene glycol) or its sulfonate onto polymer surfaces by ozone oxidation

AU - Ko, Young Gun

AU - Kim, Young Ha

AU - Park, Ki Dong

AU - Lee, Hee Jung

AU - Lee, Won Kyu

AU - Park, Hyung Dal

AU - Kim, Soo Hyun

AU - Lee, Gil Sun

AU - Ahn, Dong June

PY - 2001/8/1

Y1 - 2001/8/1

N2 - A novel surface modification method has been developed to improve biocompatibility of polymeric biomaterials. This approach involves ozonation and then followed by graft polymerization with acrylates containing PEG, sulfonated PEG or by coupling of PEG derivatives. All the reactions were confirmed by ATR FT-IR and ESCA. The degree of ozonation measured by the iodide method was dependent on the ozone permeability of the polymers used. Surface hydrophilicity was investigated by measuring the contact angles. Ozonation itself yielded a slight increase in hydrophilicity and a decrease in platelet adhesion, but PEG immobilization showed a significant effect on surface hydrophilicity and platelet adhesion to confirm well-known PEG's passivity which minimize the adhesion of blood components on polymer surfaces. Both graft polymerization and coupling were effective for PU. In contrast, only grafting gave enough yields for PMMA and silicone. Platelet adhesion results demonstrated that all PEG modified surfaces adsorbed lower platelet adhesion than untreated or ozonated ones. Polymers coupled with sulfonated PEG exhibited the lowest platelet adhesion when compared with control and PEG coupled ones by virtue of the synergistic effect of non-adhesive PEG and negatively charged SO3 groups. This PEG or sulfonated PEG immobilization technology using ozonation is relatively simple for introducing uniform surface modification and therefore very useful for practical application of blood contacting medical devices.

AB - A novel surface modification method has been developed to improve biocompatibility of polymeric biomaterials. This approach involves ozonation and then followed by graft polymerization with acrylates containing PEG, sulfonated PEG or by coupling of PEG derivatives. All the reactions were confirmed by ATR FT-IR and ESCA. The degree of ozonation measured by the iodide method was dependent on the ozone permeability of the polymers used. Surface hydrophilicity was investigated by measuring the contact angles. Ozonation itself yielded a slight increase in hydrophilicity and a decrease in platelet adhesion, but PEG immobilization showed a significant effect on surface hydrophilicity and platelet adhesion to confirm well-known PEG's passivity which minimize the adhesion of blood components on polymer surfaces. Both graft polymerization and coupling were effective for PU. In contrast, only grafting gave enough yields for PMMA and silicone. Platelet adhesion results demonstrated that all PEG modified surfaces adsorbed lower platelet adhesion than untreated or ozonated ones. Polymers coupled with sulfonated PEG exhibited the lowest platelet adhesion when compared with control and PEG coupled ones by virtue of the synergistic effect of non-adhesive PEG and negatively charged SO3 groups. This PEG or sulfonated PEG immobilization technology using ozonation is relatively simple for introducing uniform surface modification and therefore very useful for practical application of blood contacting medical devices.

KW - Ozone treatment

KW - PEG/PEG-SO immobilization

KW - Platelet adhesion

KW - Wettability

UR - http://www.scopus.com/inward/record.url?scp=0035424552&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035424552&partnerID=8YFLogxK

U2 - 10.1016/S0142-9612(00)00400-2

DO - 10.1016/S0142-9612(00)00400-2

M3 - Article

C2 - 11432591

AN - SCOPUS:0035424552

VL - 22

SP - 2115

EP - 2123

JO - Biomaterials

JF - Biomaterials

SN - 0142-9612

IS - 15

ER -