Immobilized polydiacetylene vesicle for label-free biosensor

Kyung Woo Kim, Moo Kyung Park, Hyun Choi, Dong June Ahn, Min-Kyu Oh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The polydiacetylene vesicles-based sensors have been of interest due to their unique chromatic properties, such as blue-to-red color transition. The liposome-like vesicles were immobilized on solid substrates using various polydiacetylene derivatives synthesized with different functional groups, such as, amine, carboxylic acid, and biotin, etc. Through their fluorogenic properties, the label-free biosensor was constructed with PDA immobilized on the solid substrate. Here, we showed some results of our recent studies to construct label-free sensors for detecting protein and bacterial cells using the stress-induced fluorescence emission of PDA vesicles. From the results, we anticipate that the system of micro-patterned PDA-based biosensor can be used to fabricate a label-free diagnostic sensor.

Original languageEnglish
Title of host publication2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010
Pages865-868
Number of pages4
DOIs
Publication statusPublished - 2010 Nov 29
Event5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010 - Xiamen, China
Duration: 2010 Jan 202010 Jan 23

Other

Other5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010
CountryChina
CityXiamen
Period10/1/2010/1/23

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Keywords

  • Dimyristoyl phosphatidylcholine (DMPC)
  • Label-free biosensor
  • Microarray
  • Polydiacetylene

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Electrical and Electronic Engineering

Cite this

Kim, K. W., Park, M. K., Choi, H., Ahn, D. J., & Oh, M-K. (2010). Immobilized polydiacetylene vesicle for label-free biosensor. In 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010 (pp. 865-868). [5592171] https://doi.org/10.1109/NEMS.2010.5592171