Immobilized polydiacetylene vesicle for label-free biosensor

Kyung Woo Kim; Moo Kyung Park; Hyun Choi; Dong June Ahn; Min Kyu Oh

doi:10.1109/NEMS.2010.5592171

Immobilized polydiacetylene vesicle for label-free biosensor

Kyung Woo Kim, Moo Kyung Park, Hyun Choi, Dong June Ahn, Min Kyu Oh

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The polydiacetylene vesicles-based sensors have been of interest due to their unique chromatic properties, such as blue-to-red color transition. The liposome-like vesicles were immobilized on solid substrates using various polydiacetylene derivatives synthesized with different functional groups, such as, amine, carboxylic acid, and biotin, etc. Through their fluorogenic properties, the label-free biosensor was constructed with PDA immobilized on the solid substrate. Here, we showed some results of our recent studies to construct label-free sensors for detecting protein and bacterial cells using the stress-induced fluorescence emission of PDA vesicles. From the results, we anticipate that the system of micro-patterned PDA-based biosensor can be used to fabricate a label-free diagnostic sensor.

Original language	English
Title of host publication	2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010
Pages	865-868
Number of pages	4
DOIs	https://doi.org/10.1109/NEMS.2010.5592171
Publication status	Published - 2010
Event	5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010 - Xiamen, China Duration: 2010 Jan 20 → 2010 Jan 23

Publication series

Name	2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010

Other

Other	5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010
Country	China
City	Xiamen
Period	10/1/20 → 10/1/23

Keywords

Dimyristoyl phosphatidylcholine (DMPC)
Label-free biosensor
Microarray
Polydiacetylene

ASJC Scopus subject areas

Control and Systems Engineering
Electrical and Electronic Engineering

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Kim, K. W., Park, M. K., Choi, H., Ahn, D. J., & Oh, M. K. (2010). Immobilized polydiacetylene vesicle for label-free biosensor. In 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010 (pp. 865-868). [5592171] (2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010). https://doi.org/10.1109/NEMS.2010.5592171

Immobilized polydiacetylene vesicle for label-free biosensor. / Kim, Kyung Woo; Park, Moo Kyung; Choi, Hyun; Ahn, Dong June ; Oh, Min Kyu.

2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010. 2010. p. 865-868 5592171 (2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kim, KW, Park, MK, Choi, H, Ahn, DJ & Oh, MK 2010, Immobilized polydiacetylene vesicle for label-free biosensor. in 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010., 5592171, 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010, pp. 865-868, 5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010, Xiamen, China, 10/1/20. https://doi.org/10.1109/NEMS.2010.5592171

Kim KW, Park MK, Choi H, Ahn DJ , Oh MK. Immobilized polydiacetylene vesicle for label-free biosensor. In 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010. 2010. p. 865-868. 5592171. (2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010). https://doi.org/10.1109/NEMS.2010.5592171

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abstract = "The polydiacetylene vesicles-based sensors have been of interest due to their unique chromatic properties, such as blue-to-red color transition. The liposome-like vesicles were immobilized on solid substrates using various polydiacetylene derivatives synthesized with different functional groups, such as, amine, carboxylic acid, and biotin, etc. Through their fluorogenic properties, the label-free biosensor was constructed with PDA immobilized on the solid substrate. Here, we showed some results of our recent studies to construct label-free sensors for detecting protein and bacterial cells using the stress-induced fluorescence emission of PDA vesicles. From the results, we anticipate that the system of micro-patterned PDA-based biosensor can be used to fabricate a label-free diagnostic sensor.",

keywords = "Dimyristoyl phosphatidylcholine (DMPC), Label-free biosensor, Microarray, Polydiacetylene",

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Immobilized polydiacetylene vesicle for label-free biosensor

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