Immobilized polydiacetylene vesicle for label-free biosensor

Kyung Woo Kim; Moo Kyung Park; Hyun Choi; Dong June Ahn; Min-Kyu Oh

doi:10.1109/NEMS.2010.5592171

Immobilized polydiacetylene vesicle for label-free biosensor

Kyung Woo Kim, Moo Kyung Park, Hyun Choi, Dong June Ahn, Min-Kyu Oh

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The polydiacetylene vesicles-based sensors have been of interest due to their unique chromatic properties, such as blue-to-red color transition. The liposome-like vesicles were immobilized on solid substrates using various polydiacetylene derivatives synthesized with different functional groups, such as, amine, carboxylic acid, and biotin, etc. Through their fluorogenic properties, the label-free biosensor was constructed with PDA immobilized on the solid substrate. Here, we showed some results of our recent studies to construct label-free sensors for detecting protein and bacterial cells using the stress-induced fluorescence emission of PDA vesicles. From the results, we anticipate that the system of micro-patterned PDA-based biosensor can be used to fabricate a label-free diagnostic sensor.

Original language	English
Title of host publication	2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010
Pages	865-868
Number of pages	4
DOIs	https://doi.org/10.1109/NEMS.2010.5592171
Publication status	Published - 2010 Nov 29
Event	5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010 - Xiamen, China Duration: 2010 Jan 20 → 2010 Jan 23

Other

Other	5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010
Country	China
City	Xiamen
Period	10/1/20 → 10/1/23

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Keywords

Dimyristoyl phosphatidylcholine (DMPC)
Label-free biosensor
Microarray
Polydiacetylene

ASJC Scopus subject areas

Control and Systems Engineering
Electrical and Electronic Engineering

Cite this

Kim, K. W., Park, M. K., Choi, H., Ahn, D. J., & Oh, M-K. (2010). Immobilized polydiacetylene vesicle for label-free biosensor. In 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010 (pp. 865-868). [5592171] https://doi.org/10.1109/NEMS.2010.5592171

Kim, KW, Park, MK, Choi, H, Ahn, DJ & Oh, M-K 2010, Immobilized polydiacetylene vesicle for label-free biosensor. in 2010 IEEE 5th International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010., 5592171, pp. 865-868, 5th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2010, Xiamen, China, 10/1/20. https://doi.org/10.1109/NEMS.2010.5592171

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abstract = "The polydiacetylene vesicles-based sensors have been of interest due to their unique chromatic properties, such as blue-to-red color transition. The liposome-like vesicles were immobilized on solid substrates using various polydiacetylene derivatives synthesized with different functional groups, such as, amine, carboxylic acid, and biotin, etc. Through their fluorogenic properties, the label-free biosensor was constructed with PDA immobilized on the solid substrate. Here, we showed some results of our recent studies to construct label-free sensors for detecting protein and bacterial cells using the stress-induced fluorescence emission of PDA vesicles. From the results, we anticipate that the system of micro-patterned PDA-based biosensor can be used to fabricate a label-free diagnostic sensor.",

keywords = "Dimyristoyl phosphatidylcholine (DMPC), Label-free biosensor, Microarray, Polydiacetylene",

author = "Kim, {Kyung Woo} and Park, {Moo Kyung} and Hyun Choi and Ahn, {Dong June} and Min-Kyu Oh",

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Access to Document

10.1109/NEMS.2010.5592171