Immune Defects in 28-kDa Proteasome Activator γ-Deficient Mice

Lance F. Barton, Herbert A. Runnels, Todd D. Schell, Yunjung Cho, Reta Gibbons, Satvir S. Tevethia, George S. Deepe, John J. Monaco

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)

Abstract

Protein complexes of the 28-kDa proteasome activator (PA28) family activate the proteasome and may alter proteasome cleavage specificity. Initial investigations have demonstrated a role for the IFN-γ-inducible PA28α/β complex in Ag processing. Although the noninducible and predominantly nuclear PA28γ complex has been implicated in affecting proteasome-dependent signaling pathways, such as control of the mitotic cell cycle, there is no previous evidence demonstrating a role for this structure in Ag processing. We therefore generated PA28γ-deficient mice and investigated their immune function. PA28γ-/- mice display a slight reduction In CD8+ T cell numbers and do not effectively clear a pulmonary fungal infection. However, T cell responses in two viral infection models appear normal in both magnitude and the hierarchy of antigenic epitopes recognized. We conclude that PA28γ-/- mice, like PA28α-/--/- mice, are deficient in the processing of only specific Ags.

Original languageEnglish
Pages (from-to)3948-3954
Number of pages7
JournalJournal of Immunology
Volume172
Issue number6
DOIs
Publication statusPublished - 2004 Mar 15

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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