Immune enhancing effect of a Maillard-type lysozyme-galactomannan conjugate via signaling pathways

Young min Ha, Su Hyun Chun, Seung taek Hong, Yun chang Koo, Hee don Choi, Kwang Won Lee

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We studied the immune-modulating effect of Maillard-type lysozyme-galactomannan conjugate (LGC). LGC significantly induced nitric oxide, and expressions of tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-8 on the murine macrophage Raw 264.7 cell line. In the mechanism of LGC, while extracellular signal-regulated kinase (ERK) was important for the induction of TNF-α, IL-1β and IL-8, the phosphorylation of C-Jun NH2-termianl kinase (JNK) contributed to the induction of TNF-α and IL-1β to a greater degree. These cytokines were less sensitive to the inhibition of p38. Nuclear factor (NF)-κB was involved in the induction of TNF-α and IL-1β. These data indicate that LGC has immune-modulating effects via JNK, ERK and NF-κB pathways, and that LGC may contribute to host immune defense.

Original languageEnglish
Pages (from-to)399-404
Number of pages6
JournalInternational Journal of Biological Macromolecules
Volume60
DOIs
Publication statusPublished - 2013 Jul 24

Fingerprint

Muramidase
Interleukin-1
Tumor Necrosis Factor-alpha
Extracellular Signal-Regulated MAP Kinases
Interleukin-8
Phosphotransferases
Phosphorylation
Macrophages
Nitric Oxide
Cells
galactomannan
Cytokines
Cell Line

Keywords

  • Galactomannan
  • Immune-modulating effect
  • Lysozyme
  • Maillard reaction

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Cite this

Immune enhancing effect of a Maillard-type lysozyme-galactomannan conjugate via signaling pathways. / Ha, Young min; Chun, Su Hyun; Hong, Seung taek; Koo, Yun chang; Choi, Hee don; Lee, Kwang Won.

In: International Journal of Biological Macromolecules, Vol. 60, 24.07.2013, p. 399-404.

Research output: Contribution to journalArticle

Ha, Young min ; Chun, Su Hyun ; Hong, Seung taek ; Koo, Yun chang ; Choi, Hee don ; Lee, Kwang Won. / Immune enhancing effect of a Maillard-type lysozyme-galactomannan conjugate via signaling pathways. In: International Journal of Biological Macromolecules. 2013 ; Vol. 60. pp. 399-404.
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AU - Choi, Hee don

AU - Lee, Kwang Won

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