Immune enhancing effect of a Maillard-type lysozyme-galactomannan conjugate via signaling pathways

Young min Ha, Su Hyun Chun, Seung taek Hong, Yun chang Koo, Hee don Choi, Kwang won Lee

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

We studied the immune-modulating effect of Maillard-type lysozyme-galactomannan conjugate (LGC). LGC significantly induced nitric oxide, and expressions of tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-8 on the murine macrophage Raw 264.7 cell line. In the mechanism of LGC, while extracellular signal-regulated kinase (ERK) was important for the induction of TNF-α, IL-1β and IL-8, the phosphorylation of C-Jun NH2-termianl kinase (JNK) contributed to the induction of TNF-α and IL-1β to a greater degree. These cytokines were less sensitive to the inhibition of p38. Nuclear factor (NF)-κB was involved in the induction of TNF-α and IL-1β. These data indicate that LGC has immune-modulating effects via JNK, ERK and NF-κB pathways, and that LGC may contribute to host immune defense.

Original languageEnglish
Pages (from-to)399-404
Number of pages6
JournalInternational Journal of Biological Macromolecules
Volume60
DOIs
Publication statusPublished - 2013

Keywords

  • Galactomannan
  • Immune-modulating effect
  • Lysozyme
  • Maillard reaction

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Economics and Econometrics
  • Energy(all)

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