Immune-mediated tumor evolution

Nanog links the emergence of a stem like cancer cell state and immune evasion

Chih Ping Mao, T. C. Wu, Kwon Ho Song, Tae Woo Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state and immune evasion. Thus, therapeutic strategies aiming to blunt NANOG's expression in patient tumors may improve the clinical management of cancer.

Original languageEnglish
Article numbere947871
JournalOncoImmunology
Volume3
Issue number7
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Immune Evasion
Neoplastic Stem Cells
Pressure
Neoplasms
Molecular Evolution
Lung Neoplasms
Vaccination
Transcription Factors
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Oncology
  • Immunology

Cite this

Immune-mediated tumor evolution : Nanog links the emergence of a stem like cancer cell state and immune evasion. / Mao, Chih Ping; Wu, T. C.; Song, Kwon Ho; Kim, Tae Woo.

In: OncoImmunology, Vol. 3, No. 7, e947871, 01.01.2014.

Research output: Contribution to journalArticle

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