Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion

Chih Ping Mao; T. C. Wu; Kwon Ho Song; Tae Woo Kim

doi:10.4161/21624011.2014.947871

Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion

Chih Ping Mao, T. C. Wu, Kwon Ho Song, Tae Woo Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state and immune evasion. Thus, therapeutic strategies aiming to blunt NANOG's expression in patient tumors may improve the clinical management of cancer.

Original language	English
Article number	e947871
Journal	OncoImmunology
Volume	3
Issue number	7
DOIs	https://doi.org/10.4161/21624011.2014.947871
Publication status	Published - 2014

Keywords

Cytotoxic T lymphocytes
Immune surveillance
Immune-resistant
Nanog
Stem-like phenotype

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/21624011.2014.947871

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title = "Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion",

abstract = "Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state and immune evasion. Thus, therapeutic strategies aiming to blunt NANOG's expression in patient tumors may improve the clinical management of cancer.",

keywords = "Cytotoxic T lymphocytes, Immune surveillance, Immune-resistant, Nanog, Stem-like phenotype",

author = "Mao, {Chih Ping} and Wu, {T. C.} and Song, {Kwon Ho} and Kim, {Tae Woo}",

note = "Funding Information: This work was supported by funding from the National Research Foundation of Korea (NRF-2013M3A9D3045881, NRF-2012R1A2A2A01007527) and the Korea Healthcare technology R&D Project (A062260). Publisher Copyright: {\textcopyright} 2014 Taylor & Francis Group, LLC.",

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doi = "10.4161/21624011.2014.947871",

language = "English",

volume = "3",

journal = "OncoImmunology",

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T2 - Nanog links the emergence of a stem like cancer cell state and immune evasion

AU - Mao, Chih Ping

AU - Wu, T. C.

AU - Song, Kwon Ho

AU - Kim, Tae Woo

N1 - Funding Information: This work was supported by funding from the National Research Foundation of Korea (NRF-2013M3A9D3045881, NRF-2012R1A2A2A01007527) and the Korea Healthcare technology R&D Project (A062260). Publisher Copyright: © 2014 Taylor & Francis Group, LLC.

PY - 2014

Y1 - 2014

N2 - Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state and immune evasion. Thus, therapeutic strategies aiming to blunt NANOG's expression in patient tumors may improve the clinical management of cancer.

AB - Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state and immune evasion. Thus, therapeutic strategies aiming to blunt NANOG's expression in patient tumors may improve the clinical management of cancer.

KW - Cytotoxic T lymphocytes

KW - Immune surveillance

KW - Immune-resistant

KW - Nanog

KW - Stem-like phenotype

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JO - OncoImmunology

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ER -

Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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