Immune-modulating activity of extract prepared from mycelial culture of Chinese caterpillar mushroom, ophiocordyceps sinensis (Ascomycetes)

Sun Hee Jang, Sae Hae Kim, Ha Yan Lee, Seung Hwan Jang, Hyon Seok Jang, Soo Wan Chae, Su Jin Jung, Byung Ok So, Ki Chan Ha, Hong Sig Sin, Yong Suk Jang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Ophiocordyceps sinensis is a natural fungus that has been valued as a health food and traditional Chinese medicine for centuries. The fungus is parasitic and colonizes insect larva. Naturally occurring O. sinensis thrives at high altitude in cold and grassy alpine meadows on the Himalayan mountain ranges. Wild O. sinensis is becoming increasingly rare in its natural habitats, and its price is out of reach for clinical practice. For these reasons, development of a standardized alternative is a great focus of research to allow the use of O. sinensis as a medicine. To develop an alternative for wild O. sinensis, a refined standardized extract, CBG-CS-2, was produced by artificial fermentation and extraction of the mycelial strain Paecilomyces hepiali CBG-CS-1, which originated from wild O. sinensis. In this study, we analyzed the in vivo immune-modulating effect of CBG-CS-2 in mice. Oral administration of CBG-CS-2 supported splenocyte stimulation and enhanced Th1-type cytokine expression from the splenocytes. Importantly, the same treatment significantly enhanced the natural killer cell activity of the splenocytes. Finally, oral administration of CBG-CS-2 enhanced the potential for inflammatory responses. Together, these findings indicate that the mycelial culture extract prepared from O. sinensis exhibited immune-modulating activity and suggest its possible use in the treatment of diseases caused by abnormal immune function.

Original languageEnglish
Pages (from-to)1189-1199
Number of pages11
JournalInternational Journal of Medicinal Mushrooms
Issue number12
Publication statusPublished - 2015 Jan 1


  • Immune modulation
  • Inflammation
  • Medicinal mushrooms
  • Mycelial extract
  • NK cell
  • Ophiocordyceps sinensis

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Pharmacology
  • Drug Discovery

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