Immune reactions and allergy in experimental anisakiasis.

Sung Weon Cho, Haneul Nari Lee

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)


The third-stage larvae (L3) of the parasitic nematode, Anisakis simplex, have been implicated in the induction of hyperimmune allergic reactions in orally infected humans. In this work, we have conducted a review of an investigation into immune reactions occurring in animals experimentally infected with A. simplex L3. The patterns of serum antibody productions in the experimental animals against excretory-secretory products (ESP) of A. simplex L3 contributed to our current knowledge regarding specific humoral immune reactions in humans. In our review, we were able to determine that L3 infection of experimental animals may constitute a good model system for further exploration of immune mechanisms and allergy in anisakiasis of humans.

Original languageEnglish
Pages (from-to)271-283
Number of pages13
JournalThe Korean journal of parasitology
Issue number4
Publication statusPublished - 2006 Dec
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases


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