Immune responses to a recombinant glycoprotein e herpes zoster vaccine in adults aged 50 years or older

for the ZOE-50/70 Study Group

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Background. The herpes zoster subunit vaccine (HZ/su), consisting of varicella-zoster virus glycoprotein E (gE) and AS01B Adjuvant System, was highly efficacious in preventing herpes zoster in the ZOE-50 and ZOE-70 trials. We present immunogenicity results from those trials. Methods. Participants (ZOE-50: ≥50; ZOE-70: ≥70 years of age) received 2 doses of HZ/su or placebo, 2 months apart. Serum anti-gE antibodies and CD4 T cells expressing ≥2 of 4 activation markers assessed (CD42+) after stimulation with gE-peptides were measured in subcohorts for humoral (n = 3293) and cell-mediated (n = 466) immunogenicity. Results. After vaccination, 97.8% of HZ/su and 2.0% of placebo recipients showed a humoral response. Geometric mean anti-gE antibody concentrations increased 39.1-fold and 8.3-fold over baseline in HZ/su recipients at 1 and 36 months post-dose 2, respectively. A gE-specific CD42+ T-cell response was shown in 93.3% of HZ/su and 0% of placebo recipients. Median CD42+ T-cell frequencies increased 24.6-fold (1 month) and 7.9-fold (36 months) over baseline in HZ/su recipients and remained ≥5.6-fold above baseline in all age groups at 36 months. The proportion of CD4 T cells expressing all 4 activation markers increased over time in all age groups. Conclusions. Most HZ/su recipients developed robust immune responses persisting for 3 years following vaccination.

Original languageEnglish
Pages (from-to)1750-1760
Number of pages11
JournalJournal of Infectious Diseases
Volume217
Issue number11
DOIs
Publication statusPublished - 2018 Jun 1

Keywords

  • Adjuvant system
  • GE subunit vaccine
  • Herpes zoster vaccine
  • Immunogenicity
  • Varicella-zoster virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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