Immunity and the burden of herpes zoster

Wonseok Choi, Soon Sun Kwon, Jacob Lee, Su Mi Choi, Jin Soo Lee, Joong Sik Eom, Jang Wook Sohn, Hee Jin Choeng

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The burden of herpes zoster may be related to patients' immunity, although this has not been studied extensively. This hypothesis was tested in a matched case-control study of patients with herpes zoster who sought treatment at one of seven university hospitals in Korea from January 1, 2007, to December 31, 2010. Patients diagnosed with herpes zoster were placed into three groups based on their immune status: severely immunocompromised, mild-to-moderately immunocompromised, and normal immunity. Each patient in the severely immunocompromised group was matched with one patient in the mild-to-moderately immunocompromised group and one patient in the normal immunity group in the same hospital based on age, sex, and date of herpes zoster onset. A total of 582 patients with herpes zoster were included in the analysis: 194 in each of the three groups. Patients in the severely immunocompromised group had the highest herpes zoster-related hospitalization rate as compared to patients in the mild-to-moderately immunocompromised and normal immune groups (P<0.01). The length of hospital stay and herpes zoster-related medical cost increased significantly with the deterioration of patients' immunity (P<0.01, respectively). Cutaneous complications occurred more frequently in the severely immunocompromised group than in the other two groups (P<0.01). An increase in herpes zoster burden was observed as the patients' immunity decreased. Therefore, effective measures are necessary to prevent herpes zoster and reduce its burden in severely immunocompromised patients. J. Med. Virol. 86:525-530, 2014.

Original languageEnglish
Pages (from-to)525-530
Number of pages6
JournalJournal of Medical Virology
Volume86
Issue number3
DOIs
Publication statusPublished - 2014 Mar 1

Fingerprint

Herpes Zoster
Immunity
Length of Stay
Immunocompromised Host
Korea
Case-Control Studies
Hospitalization
Research Design
Costs and Cost Analysis
Skin

Keywords

  • Disease burden
  • Herpes zoster
  • Immunity

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Choi, W., Kwon, S. S., Lee, J., Choi, S. M., Lee, J. S., Eom, J. S., ... Choeng, H. J. (2014). Immunity and the burden of herpes zoster. Journal of Medical Virology, 86(3), 525-530. https://doi.org/10.1002/jmv.23830

Immunity and the burden of herpes zoster. / Choi, Wonseok; Kwon, Soon Sun; Lee, Jacob; Choi, Su Mi; Lee, Jin Soo; Eom, Joong Sik; Sohn, Jang Wook; Choeng, Hee Jin.

In: Journal of Medical Virology, Vol. 86, No. 3, 01.03.2014, p. 525-530.

Research output: Contribution to journalArticle

Choi, W, Kwon, SS, Lee, J, Choi, SM, Lee, JS, Eom, JS, Sohn, JW & Choeng, HJ 2014, 'Immunity and the burden of herpes zoster', Journal of Medical Virology, vol. 86, no. 3, pp. 525-530. https://doi.org/10.1002/jmv.23830
Choi W, Kwon SS, Lee J, Choi SM, Lee JS, Eom JS et al. Immunity and the burden of herpes zoster. Journal of Medical Virology. 2014 Mar 1;86(3):525-530. https://doi.org/10.1002/jmv.23830
Choi, Wonseok ; Kwon, Soon Sun ; Lee, Jacob ; Choi, Su Mi ; Lee, Jin Soo ; Eom, Joong Sik ; Sohn, Jang Wook ; Choeng, Hee Jin. / Immunity and the burden of herpes zoster. In: Journal of Medical Virology. 2014 ; Vol. 86, No. 3. pp. 525-530.
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