Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans

Suk Kyun Yang, Myunghee Hong, Hyunchul Choi, Wanting Zhao, Yusun Jung, Talin Haritunians, Byong Duk Ye, Kyung Jo Kim, Sang Hyoung Park, Inchul Lee, Won Ho Kim, Jae Hee Cheon, Young Ho Kim, Byung Ik Jang, Hyun Soo Kim, Jai Hyun Choi, Ja Seol Koo, Ji Hyun Lee, Sung Ae Jung, Hyoung Doo ShinDaehee Kang, Hee Shang Youn, Kent D. Taylor, Jerome I. Rotter, Jianjun Liu, Dermot P.B. McGovern, Kyuyoung Song

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Crohn's disease (CD) is an intractable inflammatory bowel disease of unknown cause. Recent genome-wide association studies of CD in Korean and Japanese populations suggested marginal sharing of susceptibility loci between Caucasian and Asian populations. As the 7 identified loci altogether explain 5.31% of the risk for CD, the objective of this study was to identify additional CD susceptibility loci in the Korean population. Methods: Using the ImmunoChip custom single-nucleotide polymorphism array designed for dense genotyping of 186 loci identified through GWAS, we analyzed 722 individuals with CD and 461 controls for 96,048 SNP markers in the discovery stage, followed by validation in an additional 948 affected individuals and 977 controls. Results: We confirmed 6 previously reported loci in Caucasian: GPR35 at 2q37 (rs3749172; P = 5.30 • 10-11, odds ratio [OR] = 1.45), ZNF365 at 10q21 (rs224143; P = 2.20 • 10-9, OR = 1.38), ZMIZ1 at 10q22 (rs1250569; P = 3.05 • 10-7, OR = 1.30), NKX2-3 at 10q24 (rs4409764; P = 7.93 • 10-8, OR = 1.32), PTPN2 at 18p11 (rs514000; P = 9.00 • 10-8, OR = 1.33), and USP25 at 21q11 (rs2823256; P = 2.49 • 10-7, OR = 1.35), bringing the number of known CD loci (including 3 in the HLA) in Koreans to 15. The 6 additional loci increased the total genetic variance for CD risk from 5.31% to 7.27% in Koreans. Conclusions: Although the different genetic backgrounds of CD between Asian and Western countries has been well established for the major susceptibility genes, our findings of overlapping associations offer new insights into the genetic architecture of CD.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalInflammatory Bowel Diseases
Volume21
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Crohn Disease
Odds Ratio
Genome-Wide Association Study
Single Nucleotide Polymorphism
Population
Disease Susceptibility
Inflammatory Bowel Diseases
Genes

Keywords

  • Crohn's disease
  • Genetics
  • ImmunoChip
  • Korean

ASJC Scopus subject areas

  • Immunology and Allergy
  • Gastroenterology

Cite this

Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans. / Yang, Suk Kyun; Hong, Myunghee; Choi, Hyunchul; Zhao, Wanting; Jung, Yusun; Haritunians, Talin; Ye, Byong Duk; Kim, Kyung Jo; Park, Sang Hyoung; Lee, Inchul; Kim, Won Ho; Cheon, Jae Hee; Kim, Young Ho; Jang, Byung Ik; Kim, Hyun Soo; Choi, Jai Hyun; Koo, Ja Seol; Lee, Ji Hyun; Jung, Sung Ae; Shin, Hyoung Doo; Kang, Daehee; Youn, Hee Shang; Taylor, Kent D.; Rotter, Jerome I.; Liu, Jianjun; McGovern, Dermot P.B.; Song, Kyuyoung.

In: Inflammatory Bowel Diseases, Vol. 21, No. 1, 01.01.2015, p. 1-7.

Research output: Contribution to journalArticle

Yang, SK, Hong, M, Choi, H, Zhao, W, Jung, Y, Haritunians, T, Ye, BD, Kim, KJ, Park, SH, Lee, I, Kim, WH, Cheon, JH, Kim, YH, Jang, BI, Kim, HS, Choi, JH, Koo, JS, Lee, JH, Jung, SA, Shin, HD, Kang, D, Youn, HS, Taylor, KD, Rotter, JI, Liu, J, McGovern, DPB & Song, K 2015, 'Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans', Inflammatory Bowel Diseases, vol. 21, no. 1, pp. 1-7. https://doi.org/10.1097/MIB.0000000000000268
Yang, Suk Kyun ; Hong, Myunghee ; Choi, Hyunchul ; Zhao, Wanting ; Jung, Yusun ; Haritunians, Talin ; Ye, Byong Duk ; Kim, Kyung Jo ; Park, Sang Hyoung ; Lee, Inchul ; Kim, Won Ho ; Cheon, Jae Hee ; Kim, Young Ho ; Jang, Byung Ik ; Kim, Hyun Soo ; Choi, Jai Hyun ; Koo, Ja Seol ; Lee, Ji Hyun ; Jung, Sung Ae ; Shin, Hyoung Doo ; Kang, Daehee ; Youn, Hee Shang ; Taylor, Kent D. ; Rotter, Jerome I. ; Liu, Jianjun ; McGovern, Dermot P.B. ; Song, Kyuyoung. / Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans. In: Inflammatory Bowel Diseases. 2015 ; Vol. 21, No. 1. pp. 1-7.
@article{d5024c87c9ea4429803331d18dbed1aa,
title = "Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans",
abstract = "Background: Crohn's disease (CD) is an intractable inflammatory bowel disease of unknown cause. Recent genome-wide association studies of CD in Korean and Japanese populations suggested marginal sharing of susceptibility loci between Caucasian and Asian populations. As the 7 identified loci altogether explain 5.31{\%} of the risk for CD, the objective of this study was to identify additional CD susceptibility loci in the Korean population. Methods: Using the ImmunoChip custom single-nucleotide polymorphism array designed for dense genotyping of 186 loci identified through GWAS, we analyzed 722 individuals with CD and 461 controls for 96,048 SNP markers in the discovery stage, followed by validation in an additional 948 affected individuals and 977 controls. Results: We confirmed 6 previously reported loci in Caucasian: GPR35 at 2q37 (rs3749172; P = 5.30 • 10-11, odds ratio [OR] = 1.45), ZNF365 at 10q21 (rs224143; P = 2.20 • 10-9, OR = 1.38), ZMIZ1 at 10q22 (rs1250569; P = 3.05 • 10-7, OR = 1.30), NKX2-3 at 10q24 (rs4409764; P = 7.93 • 10-8, OR = 1.32), PTPN2 at 18p11 (rs514000; P = 9.00 • 10-8, OR = 1.33), and USP25 at 21q11 (rs2823256; P = 2.49 • 10-7, OR = 1.35), bringing the number of known CD loci (including 3 in the HLA) in Koreans to 15. The 6 additional loci increased the total genetic variance for CD risk from 5.31{\%} to 7.27{\%} in Koreans. Conclusions: Although the different genetic backgrounds of CD between Asian and Western countries has been well established for the major susceptibility genes, our findings of overlapping associations offer new insights into the genetic architecture of CD.",
keywords = "Crohn's disease, Genetics, ImmunoChip, Korean",
author = "Yang, {Suk Kyun} and Myunghee Hong and Hyunchul Choi and Wanting Zhao and Yusun Jung and Talin Haritunians and Ye, {Byong Duk} and Kim, {Kyung Jo} and Park, {Sang Hyoung} and Inchul Lee and Kim, {Won Ho} and Cheon, {Jae Hee} and Kim, {Young Ho} and Jang, {Byung Ik} and Kim, {Hyun Soo} and Choi, {Jai Hyun} and Koo, {Ja Seol} and Lee, {Ji Hyun} and Jung, {Sung Ae} and Shin, {Hyoung Doo} and Daehee Kang and Youn, {Hee Shang} and Taylor, {Kent D.} and Rotter, {Jerome I.} and Jianjun Liu and McGovern, {Dermot P.B.} and Kyuyoung Song",
year = "2015",
month = "1",
day = "1",
doi = "10.1097/MIB.0000000000000268",
language = "English",
volume = "21",
pages = "1--7",
journal = "Inflammatory Bowel Diseases",
issn = "1078-0998",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans

AU - Yang, Suk Kyun

AU - Hong, Myunghee

AU - Choi, Hyunchul

AU - Zhao, Wanting

AU - Jung, Yusun

AU - Haritunians, Talin

AU - Ye, Byong Duk

AU - Kim, Kyung Jo

AU - Park, Sang Hyoung

AU - Lee, Inchul

AU - Kim, Won Ho

AU - Cheon, Jae Hee

AU - Kim, Young Ho

AU - Jang, Byung Ik

AU - Kim, Hyun Soo

AU - Choi, Jai Hyun

AU - Koo, Ja Seol

AU - Lee, Ji Hyun

AU - Jung, Sung Ae

AU - Shin, Hyoung Doo

AU - Kang, Daehee

AU - Youn, Hee Shang

AU - Taylor, Kent D.

AU - Rotter, Jerome I.

AU - Liu, Jianjun

AU - McGovern, Dermot P.B.

AU - Song, Kyuyoung

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: Crohn's disease (CD) is an intractable inflammatory bowel disease of unknown cause. Recent genome-wide association studies of CD in Korean and Japanese populations suggested marginal sharing of susceptibility loci between Caucasian and Asian populations. As the 7 identified loci altogether explain 5.31% of the risk for CD, the objective of this study was to identify additional CD susceptibility loci in the Korean population. Methods: Using the ImmunoChip custom single-nucleotide polymorphism array designed for dense genotyping of 186 loci identified through GWAS, we analyzed 722 individuals with CD and 461 controls for 96,048 SNP markers in the discovery stage, followed by validation in an additional 948 affected individuals and 977 controls. Results: We confirmed 6 previously reported loci in Caucasian: GPR35 at 2q37 (rs3749172; P = 5.30 • 10-11, odds ratio [OR] = 1.45), ZNF365 at 10q21 (rs224143; P = 2.20 • 10-9, OR = 1.38), ZMIZ1 at 10q22 (rs1250569; P = 3.05 • 10-7, OR = 1.30), NKX2-3 at 10q24 (rs4409764; P = 7.93 • 10-8, OR = 1.32), PTPN2 at 18p11 (rs514000; P = 9.00 • 10-8, OR = 1.33), and USP25 at 21q11 (rs2823256; P = 2.49 • 10-7, OR = 1.35), bringing the number of known CD loci (including 3 in the HLA) in Koreans to 15. The 6 additional loci increased the total genetic variance for CD risk from 5.31% to 7.27% in Koreans. Conclusions: Although the different genetic backgrounds of CD between Asian and Western countries has been well established for the major susceptibility genes, our findings of overlapping associations offer new insights into the genetic architecture of CD.

AB - Background: Crohn's disease (CD) is an intractable inflammatory bowel disease of unknown cause. Recent genome-wide association studies of CD in Korean and Japanese populations suggested marginal sharing of susceptibility loci between Caucasian and Asian populations. As the 7 identified loci altogether explain 5.31% of the risk for CD, the objective of this study was to identify additional CD susceptibility loci in the Korean population. Methods: Using the ImmunoChip custom single-nucleotide polymorphism array designed for dense genotyping of 186 loci identified through GWAS, we analyzed 722 individuals with CD and 461 controls for 96,048 SNP markers in the discovery stage, followed by validation in an additional 948 affected individuals and 977 controls. Results: We confirmed 6 previously reported loci in Caucasian: GPR35 at 2q37 (rs3749172; P = 5.30 • 10-11, odds ratio [OR] = 1.45), ZNF365 at 10q21 (rs224143; P = 2.20 • 10-9, OR = 1.38), ZMIZ1 at 10q22 (rs1250569; P = 3.05 • 10-7, OR = 1.30), NKX2-3 at 10q24 (rs4409764; P = 7.93 • 10-8, OR = 1.32), PTPN2 at 18p11 (rs514000; P = 9.00 • 10-8, OR = 1.33), and USP25 at 21q11 (rs2823256; P = 2.49 • 10-7, OR = 1.35), bringing the number of known CD loci (including 3 in the HLA) in Koreans to 15. The 6 additional loci increased the total genetic variance for CD risk from 5.31% to 7.27% in Koreans. Conclusions: Although the different genetic backgrounds of CD between Asian and Western countries has been well established for the major susceptibility genes, our findings of overlapping associations offer new insights into the genetic architecture of CD.

KW - Crohn's disease

KW - Genetics

KW - ImmunoChip

KW - Korean

UR - http://www.scopus.com/inward/record.url?scp=84925779171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925779171&partnerID=8YFLogxK

U2 - 10.1097/MIB.0000000000000268

DO - 10.1097/MIB.0000000000000268

M3 - Article

C2 - 25489960

AN - SCOPUS:84925779171

VL - 21

SP - 1

EP - 7

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

SN - 1078-0998

IS - 1

ER -