Immunogenicity of trivalent influenza vaccines in patients with chronic kidney disease undergoing hemodialysis: MF59-adjuvanted versus non-adjuvanted vaccines

Ji Yun Noh, Joon Young Song, Won Suk Choi, Jacob Lee, Yu Bin Seo, Young Joo Kwon, Gang Jee Ko, Dae Ryong Cha, Young Sun Kang, Young Ki Lee, Hee Jin Cheong, Woo Joo Kim

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    Backgrounds: Patients with chronic kidney disease (CKD) are at an increased risk of morbidity and mortality from influenza. However, the immunogenicity of influenza vaccine is known to be attenuated in these patients. In this study, the immunogenicity of MF59-adjuvanted and non-adjuvanted trivalent influenza vaccines was compared in CKD patients undergoing hemodialysis (HD). Methods: During 2013–2014, 179 CKD patients undergoing HD participated in the study. The patients were randomized into either MF59-adjuvanted vaccine group or non-adjuvanted vaccine group and were immunized with the respective vaccine. Sera were collected prior to vaccination and at 1 month (88 patients in MF59-adjuvanted vaccine group and 86 patients in non-adjuvanted vaccine group) and 6 months post vaccination. Levels of hemagglutination inhibition antibodies were measured. Results: The seroconversion rate of all 3 vaccine strains at 1 month post-vaccination was significantly higher in the MF59-adjuvanted group than in the non-adjuvanted group (47.7% vs. 17.4%, A/H1N1; 42.0% vs. 16.3%, A/H3N2; 31.8% vs. 7.0%, B, P < 0.01). One month post-vaccination, the fold increase in geometric mean titer from pre-vaccination for A/H1N1, A/H3N2 and B viruses was significantly greater in the MF59-adjuvanted group than in the non-adjuvanted group. In elderly patients (≥65 years), the seroconversion rate at 1 month post-vaccination against influenza B strain was higher in the MF59-adjuvanted group than in the non-adjuvanted group (33.3% vs. 7.1%, P = 0.03). Conclusion: The MF59-adjuvanted influenza vaccine showed better immunogenicity than the non-adjuvanted influenza vaccine in CKD patients undergoing HD.

    Original languageEnglish
    Pages (from-to)2902-2908
    Number of pages7
    JournalHuman Vaccines and Immunotherapeutics
    Volume12
    Issue number11
    DOIs
    Publication statusPublished - 2016 Nov 1

    Keywords

    • MF59 oil emulsion
    • influenza vaccines
    • renal dialysis

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Immunology
    • Pharmacology

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