Abstract
The expression patterns of CD44s and CD44v6 were immunohistochemically compared with those of normal, hyperplastic and malignant endometrium. In normal endometria (n=37), endometrioses (n=46) and adenomyoses (n=20), the surface and glandular epithelial cells were negative for CD44s and CD44v6 in a proliferative pattern and positive in a secretory pattern, whereas the stroma was only positive for CD44s in both proliferative and secretory patterns. The endometrial hyperplasia (4 simple and 9 complex) had the identical patterns with normal proliferative phase of endometrium. Only one case showing complex hyperplasia with atypia was focally positive for CD44s and CD44v6 in glandular epithelia. CD44s and CD44v6 were positive in all endometrial adenocarcinomas (13), except one CD44s-negative case. In summary, the expressions of CD44s and CD44v6 in endometriosis and adenomyosis recapitulated those of normal cyclic endometrium. The expression patterns in endometrial hyperplasia were similar to those in normal proliferative endometrium, whereas the endometrial adenocarcinoma showed abnormal expressions for CD44s and CD44v6. Thus it was considered that the ectopic endometrium in endometriosis and adenomyosis was not aberrant as in endometrial carcinoma on the aspects of immunohistochemical expressions of CD44s and CD44v6.
| Original language | English |
|---|---|
| Pages (from-to) | 317-322 |
| Number of pages | 6 |
| Journal | Journal of Korean Medical Science |
| Volume | 16 |
| Issue number | 3 |
| Publication status | Published - 2001 Jun 1 |
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Keywords
- Antigens
- CD44
- Endometrial Hyperplasia
- Endometrial Neoplasms
- Endometriosis
ASJC Scopus subject areas
- Medicine(all)
Cite this
Immunohistochemical analysis of CD44s and CD44v6 in endometriosis and adenomyosis : Comparison with normal, hyperplastic, and malignant endometrium. / Lin, Zhenhua; Cho, Seongjin; Jeong, Hyejin; Kim, Han Kyeom; Kim, Insun.
In: Journal of Korean Medical Science, Vol. 16, No. 3, 01.06.2001, p. 317-322.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Immunohistochemical analysis of CD44s and CD44v6 in endometriosis and adenomyosis
T2 - Comparison with normal, hyperplastic, and malignant endometrium
AU - Lin, Zhenhua
AU - Cho, Seongjin
AU - Jeong, Hyejin
AU - Kim, Han Kyeom
AU - Kim, Insun
PY - 2001/6/1
Y1 - 2001/6/1
N2 - The expression patterns of CD44s and CD44v6 were immunohistochemically compared with those of normal, hyperplastic and malignant endometrium. In normal endometria (n=37), endometrioses (n=46) and adenomyoses (n=20), the surface and glandular epithelial cells were negative for CD44s and CD44v6 in a proliferative pattern and positive in a secretory pattern, whereas the stroma was only positive for CD44s in both proliferative and secretory patterns. The endometrial hyperplasia (4 simple and 9 complex) had the identical patterns with normal proliferative phase of endometrium. Only one case showing complex hyperplasia with atypia was focally positive for CD44s and CD44v6 in glandular epithelia. CD44s and CD44v6 were positive in all endometrial adenocarcinomas (13), except one CD44s-negative case. In summary, the expressions of CD44s and CD44v6 in endometriosis and adenomyosis recapitulated those of normal cyclic endometrium. The expression patterns in endometrial hyperplasia were similar to those in normal proliferative endometrium, whereas the endometrial adenocarcinoma showed abnormal expressions for CD44s and CD44v6. Thus it was considered that the ectopic endometrium in endometriosis and adenomyosis was not aberrant as in endometrial carcinoma on the aspects of immunohistochemical expressions of CD44s and CD44v6.
AB - The expression patterns of CD44s and CD44v6 were immunohistochemically compared with those of normal, hyperplastic and malignant endometrium. In normal endometria (n=37), endometrioses (n=46) and adenomyoses (n=20), the surface and glandular epithelial cells were negative for CD44s and CD44v6 in a proliferative pattern and positive in a secretory pattern, whereas the stroma was only positive for CD44s in both proliferative and secretory patterns. The endometrial hyperplasia (4 simple and 9 complex) had the identical patterns with normal proliferative phase of endometrium. Only one case showing complex hyperplasia with atypia was focally positive for CD44s and CD44v6 in glandular epithelia. CD44s and CD44v6 were positive in all endometrial adenocarcinomas (13), except one CD44s-negative case. In summary, the expressions of CD44s and CD44v6 in endometriosis and adenomyosis recapitulated those of normal cyclic endometrium. The expression patterns in endometrial hyperplasia were similar to those in normal proliferative endometrium, whereas the endometrial adenocarcinoma showed abnormal expressions for CD44s and CD44v6. Thus it was considered that the ectopic endometrium in endometriosis and adenomyosis was not aberrant as in endometrial carcinoma on the aspects of immunohistochemical expressions of CD44s and CD44v6.
KW - Antigens
KW - CD44
KW - Endometrial Hyperplasia
KW - Endometrial Neoplasms
KW - Endometriosis
UR - http://www.scopus.com/inward/record.url?scp=0035375657&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035375657&partnerID=8YFLogxK
M3 - Review article
C2 - 11410693
AN - SCOPUS:0035375657
VL - 16
SP - 317
EP - 322
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
SN - 1011-8934
IS - 3
ER -