Immunohistochemical analysis of CD44s and CD44v6 in endometriosis and adenomyosis: Comparison with normal, hyperplastic, and malignant endometrium

Zhenhua Lin, Seongjin Cho, Hyejin Jeong, Hankyeom Kim, Insun Kim

    Research output: Contribution to journalReview articlepeer-review

    7 Citations (Scopus)

    Abstract

    The expression patterns of CD44s and CD44v6 were immunohistochemically compared with those of normal, hyperplastic and malignant endometrium. In normal endometria (n=37), endometrioses (n=46) and adenomyoses (n=20), the surface and glandular epithelial cells were negative for CD44s and CD44v6 in a proliferative pattern and positive in a secretory pattern, whereas the stroma was only positive for CD44s in both proliferative and secretory patterns. The endometrial hyperplasia (4 simple and 9 complex) had the identical patterns with normal proliferative phase of endometrium. Only one case showing complex hyperplasia with atypia was focally positive for CD44s and CD44v6 in glandular epithelia. CD44s and CD44v6 were positive in all endometrial adenocarcinomas (13), except one CD44s-negative case. In summary, the expressions of CD44s and CD44v6 in endometriosis and adenomyosis recapitulated those of normal cyclic endometrium. The expression patterns in endometrial hyperplasia were similar to those in normal proliferative endometrium, whereas the endometrial adenocarcinoma showed abnormal expressions for CD44s and CD44v6. Thus it was considered that the ectopic endometrium in endometriosis and adenomyosis was not aberrant as in endometrial carcinoma on the aspects of immunohistochemical expressions of CD44s and CD44v6.

    Original languageEnglish
    Pages (from-to)317-322
    Number of pages6
    JournalJournal of Korean medical science
    Volume16
    Issue number3
    DOIs
    Publication statusPublished - 2001 Jun

    Keywords

    • Antigens
    • CD44
    • Endometrial Hyperplasia
    • Endometrial Neoplasms
    • Endometriosis

    ASJC Scopus subject areas

    • Medicine(all)

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