Immunologic research in kidney ischemia/reperfusion injury at Johns Hopkins University

Gang Jee Ko, Asif Zakaria, Karl L. Womer, Hamid Rabb

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Abstracts: Kidney ischemia/reperfusion injury (IRI) is a common and serious problem in hospitalized patients. Immune cell trafficking and leukocyte-endothelial adhesion potentiate kidney IRI. An important immunomodulatory role of T lymphocytes has been elucidated in IRI. Regulatory T cells are a lymphocyte subset that has recently been demonstrated to perform a protective role both in early injury from IRI as well as in later repair. The immune system also participates in distant organ effects during kidney IRI. Studies focusing on immune aspects of kidney IRI have enabled the discovery of promising novel therapeutic and diagnostic approaches.

Original languageEnglish
Pages (from-to)78-85
Number of pages8
JournalImmunologic Research
Volume47
Issue number1-3
DOIs
Publication statusPublished - 2010 Jul

Keywords

  • Acute kidney injury
  • Inflammation
  • Ischemia/reperfusion injury

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Immunologic research in kidney ischemia/reperfusion injury at Johns Hopkins University'. Together they form a unique fingerprint.

  • Cite this