Immunomodulatory and antigenotoxic properties of Bacillus amyloliquefaciens KU801

Na Kyoung Lee, So Yeon Kim, Hyo Ihl Chang, Eunju Park, Hyun Dong Paik

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Bacillus KU801 strain, due to its potential in the field of probiotics for animal use, was isolated from chicken feces. Strain KU801 was identified as Bacillus amyloliquefaciens KU801 based on the results of 16S rRNA sequencing. Vegetative and spore cells of S. amyloliquefaciens KU801 were resistant to artificial gastric juice and artificial bile acid. B. amyloliquefaciens KU801 was found to inhibit the production of nitric oxide (NO) and increase the production of Interleukin-1 alpha (IL-Iα). DNA damage induced by N-methyl-Ntion of ninitroso-guanidine (MNNG) was significantly inhibited, in a dose dependent manner, by preincubating MNNG together with B. amyloliquefaciens KU801. These results demonstrate the potential use of B. amyloliquefaciens KU801 as a feed additive.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalKorean Journal of Microbiology and Biotechnology
Volume41
Issue number2
DOIs
Publication statusPublished - 2013 Jun

Keywords

  • DNA damage
  • Identification
  • Irieukin-1α
  • Nitritic oxide
  • Probiotic

ASJC Scopus subject areas

  • Biotechnology
  • Microbiology
  • Applied Microbiology and Biotechnology

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