Immunomodulatory effects of antipsychotic drugs in whole blood cell cultures from healthy subjects

Eun Jeong Kim, Yong Ku Kim

Research output: Contribution to journalArticlepeer-review

Abstract

We aimed to evaluate the effects of various antipsychotics on the in vitro production of C-reactive protein (CRP) in whole blood cell cultures from healthy volunteers. The evaluation was performed using haloperidol, quetiapine, clozapine, amisulpride, and chlorpromazine. Methods: Antipsychotic agents were added to the participants' whole blood samples, and the resulting CRP levels were measured. For each agent, three different concentrations were tested: the therapeutic concentration, one-tenth the therapeutic concentration, and ten times the therapeutic concentration. The differences in CRP concentrations before and after drug administration were investigated. Results: The Friedman test showed that haloperidol, amisulpride, and chlorpromazine significantly increased CRP levels in the blood culture samples; however, clozapine and quetiapine did not increase CRP levels. In the case of chlorpromazine, elevated CRP levels were noted at all concentrations tested. Conclusion: Our study suggests that some antipsychotics elevate CRP levels in vitro. These results agree with previous studies showing that antipsychotics have immunomodulatory effects. Future research will clarify our findings and our understanding of antipsychotic drugs and their impact on immune regulation.

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalCurrent Psychiatry Research and Reviews
Volume15
Issue number4
DOIs
Publication statusPublished - 2019 Jan 1

Keywords

  • Antipsychotic agents
  • Blood cell cultures
  • C-reactive protein
  • Immune regulation
  • Inflammation
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

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