Immunomodulatory Effects of Nontoxic Glycoprotein Fraction Isolated from Rice Bran

Ho Young Park, A. Reum Yu, Hee Do Hong, H. H. Kim, Kwang Won Lee, Hee Don Choi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Rice bran, a by-product of brown rice milling, is a rich source of dietary fiber and protein, and its usage as a functional food is expected to increase. In this study, immunomodulatory effects of glycoprotein obtained from rice bran were studied in normal mice and mouse models of cyclophosphamide-induced immunosuppression. We prepared glycoprotein from rice bran by using ammonium precipitation and anion chromatography techniques. Different doses of glycoprotein from rice bran (10, 25, and 50 mg/kg) were administered orally for 28 days. On day 21, cyclophosphamide at a dose of 100 mg/kg was administered intraperitoneally. Glycoprotein from rice bran showed a significant dose-dependent restoration of the spleen index and white blood cell count in the immunocompromised mice. Glycoprotein from rice bran affected the immunomodulatory function by inducing the proliferation of splenic lymphocytes, which produce potential T and B cells. Moreover, it prevented cyclophosphamide-induced damage of Th1-type immunomodulatory function through enhanced secretion of Th1-type cytokines (interferon-γ and interleukin-12). These results indicate that glycoprotein from rice bran significantly recovered cyclophosphamide-induced immunosuppression. Based on these data, it was concluded that glycoprotein from rice bran is a potent immunomodulator and can be developed to recover the immunity of immunocompromised individuals.

Original languageEnglish
JournalPlanta Medica
DOIs
Publication statusAccepted/In press - 2016 Jan 15

Fingerprint

Glycoproteins
Cyclophosphamide
Cells
Immunosuppression
Lymphocytes
Immunologic Factors
Interleukin-12
Chromatography
Oryza
Ammonium Compounds
Functional Food
Interferons
Restoration
Dietary Proteins
Anions
Byproducts
Dietary Fiber
Blood
Leukocyte Count
Cytokines

Keywords

  • cyclophosphamide
  • cytokines
  • glycoprotein
  • immunomodulatory effect
  • rice bran

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine

Cite this

Immunomodulatory Effects of Nontoxic Glycoprotein Fraction Isolated from Rice Bran. / Park, Ho Young; Yu, A. Reum; Hong, Hee Do; Kim, H. H.; Lee, Kwang Won; Choi, Hee Don.

In: Planta Medica, 15.01.2016.

Research output: Contribution to journalArticle

Park, Ho Young ; Yu, A. Reum ; Hong, Hee Do ; Kim, H. H. ; Lee, Kwang Won ; Choi, Hee Don. / Immunomodulatory Effects of Nontoxic Glycoprotein Fraction Isolated from Rice Bran. In: Planta Medica. 2016.
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