Immunomodulatory nanodiamond aggregate-based platform for the treatment of rheumatoid arthritis

Amanda Pentecost, Min Ju Kim, Sangmin Jeon, Young Ji Ko, Ick Chan Kwon, Yury Gogotsi, Kwang Meyung Kim, Kara L. Spiller

Research output: Contribution to journalArticle

Abstract

We previously demonstrated that octadecylamine-functionalized nanodiamond (ND-ODA) and dexamethasone (Dex)-adsorbed ND-ODA (ND-ODA-Dex) promoted anti-inflammatory and pro-regenerative behavior in human macrophages in vitro. In this study, we performed a pilot study to investigate if these immunomodulatory effects translate when used as a treatment for rheumatoid arthritis in mice. Following local injection in limbs of mice with collagen type II-induced arthritis, microcomputed tomography showed that mice treated with a low dose of ND-ODA and ND-ODA-Dex did not experience bone loss to the levels observed in non-treated arthritic controls. A low dose of ND-ODA and ND-ODA-Dex also reduced macrophage infiltration and expression of pro-inflammatory mediators iNOS and tumor necrosis factor-a compared to the arthritic control, while a high dose of ND-ODA increased expression of these markers. Overall, these results suggest that ND-ODA may be useful as an inherently immunomodulatory platform, and support the need for an in-depth study, especially with respect to the effects of dose.

Original languageEnglish
Pages (from-to)163-174
Number of pages12
JournalRegenerative Biomaterials
Volume6
Issue number3
DOIs
Publication statusPublished - 2019 Jun 1

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Nanodiamonds
Macrophages
Dexamethasone
Infiltration
Collagen
Tomography
Bone
Collagen Type II
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha

Keywords

  • Biomaterial-cell interaction
  • Drug delivery
  • Nanobiomaterials

ASJC Scopus subject areas

  • Biomaterials

Cite this

Pentecost, A., Kim, M. J., Jeon, S., Ko, Y. J., Kwon, I. C., Gogotsi, Y., ... Spiller, K. L. (2019). Immunomodulatory nanodiamond aggregate-based platform for the treatment of rheumatoid arthritis. Regenerative Biomaterials, 6(3), 163-174. https://doi.org/10.1093/rb/rbz012

Immunomodulatory nanodiamond aggregate-based platform for the treatment of rheumatoid arthritis. / Pentecost, Amanda; Kim, Min Ju; Jeon, Sangmin; Ko, Young Ji; Kwon, Ick Chan; Gogotsi, Yury; Kim, Kwang Meyung; Spiller, Kara L.

In: Regenerative Biomaterials, Vol. 6, No. 3, 01.06.2019, p. 163-174.

Research output: Contribution to journalArticle

Pentecost, A, Kim, MJ, Jeon, S, Ko, YJ, Kwon, IC, Gogotsi, Y, Kim, KM & Spiller, KL 2019, 'Immunomodulatory nanodiamond aggregate-based platform for the treatment of rheumatoid arthritis', Regenerative Biomaterials, vol. 6, no. 3, pp. 163-174. https://doi.org/10.1093/rb/rbz012
Pentecost, Amanda ; Kim, Min Ju ; Jeon, Sangmin ; Ko, Young Ji ; Kwon, Ick Chan ; Gogotsi, Yury ; Kim, Kwang Meyung ; Spiller, Kara L. / Immunomodulatory nanodiamond aggregate-based platform for the treatment of rheumatoid arthritis. In: Regenerative Biomaterials. 2019 ; Vol. 6, No. 3. pp. 163-174.
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