Immunostimulating and anticancer activities of hot-water extracts from Acanthopanax senticosus and Glycyrrhiza uralensis

Jong Hyun Hwang, Hyung Joo Suh, Kwang Won Yu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

When 10 kinds of herbal medicines were fractionated into hexane, MeOH, cold-water, and hot-water extracts, hot-water extracts from Acanthopanax senticosus (AS), Glycyrrhiza uralensis (GU), Cichorium intybus (CI), and Polygonatum odoratum (PO) showed the potent intestinal immune system modulating activity (1.72-, 1.62-, 1.60-, and 1.53-fold of control at 100 μg/mL, respectively). Especially, hot-water extracts from AS (215% compared with the control) and GU (187%) also had macrophages stimulating activity and mitogenic activity of splenocytes (7.1- and 6.5-fold) at 100 μg/mL. In addition, the effects of hot-water extracts from herbal medicines on anticancer activities were studied in mice. Hot-water extracts from AS and GU enhanced cytotoxicity of natural killer cell against cancer cell, Yac-1 (37 and 34% cytotoxicity) at E/T ratio 100:1, and colon 26-M3.1 cancer cell lines had significantly inhibited (82.1 and 75.2%) in experimental lung metastasis. These results suggest that hot-water extracts from A. senticosus and G. uralensis can be used as biological response modifiers to stimulate immune system and inhibit tumor.

Original languageEnglish
Pages (from-to)1185-1190
Number of pages6
JournalFood Science and Biotechnology
Volume17
Issue number6
Publication statusPublished - 2008

Keywords

  • Anticancer activity
  • Herbal medicine
  • Hot-water extract
  • Immunostimulating activity

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

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