Immunostimulating and anticancer activities of hot-water extracts from Acanthopanax senticosus and Glycyrrhiza uralensis

Jong Hyun Hwang, Hyung Joo Suh, Kwang Won Yu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

When 10 kinds of herbal medicines were fractionated into hexane, MeOH, cold-water, and hot-water extracts, hot-water extracts from Acanthopanax senticosus (AS), Glycyrrhiza uralensis (GU), Cichorium intybus (CI), and Polygonatum odoratum (PO) showed the potent intestinal immune system modulating activity (1.72-, 1.62-, 1.60-, and 1.53-fold of control at 100 μg/mL, respectively). Especially, hot-water extracts from AS (215% compared with the control) and GU (187%) also had macrophages stimulating activity and mitogenic activity of splenocytes (7.1- and 6.5-fold) at 100 μg/mL. In addition, the effects of hot-water extracts from herbal medicines on anticancer activities were studied in mice. Hot-water extracts from AS and GU enhanced cytotoxicity of natural killer cell against cancer cell, Yac-1 (37 and 34% cytotoxicity) at E/T ratio 100:1, and colon 26-M3.1 cancer cell lines had significantly inhibited (82.1 and 75.2%) in experimental lung metastasis. These results suggest that hot-water extracts from A. senticosus and G. uralensis can be used as biological response modifiers to stimulate immune system and inhibit tumor.

Original languageEnglish
Pages (from-to)1185-1190
Number of pages6
JournalFood Science and Biotechnology
Volume17
Issue number6
Publication statusPublished - 2008 Dec 1

Fingerprint

Eleutherococcus
Glycyrrhiza uralensis
Eleutherococcus senticosus
Water
extracts
water
Herbal Medicine
herbal medicines
immune system
cytotoxicity
Polygonatum
Immune System
Polygonatum odoratum
Chicory
Neoplasms
Cichorium intybus
natural killer cells
Immunologic Factors
Hexanes
splenocytes

Keywords

  • Anticancer activity
  • Herbal medicine
  • Hot-water extract
  • Immunostimulating activity

ASJC Scopus subject areas

  • Food Science
  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Immunostimulating and anticancer activities of hot-water extracts from Acanthopanax senticosus and Glycyrrhiza uralensis. / Hwang, Jong Hyun; Suh, Hyung Joo; Yu, Kwang Won.

In: Food Science and Biotechnology, Vol. 17, No. 6, 01.12.2008, p. 1185-1190.

Research output: Contribution to journalArticle

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