Immunostimulating components from the root of Angelica gigas Nakai

K. S. Ahn, W. S. Sim, H. M. Kim, S. B. Han, I. H. Kim

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16 Citations (Scopus)

Abstract

A potent immune-stimulating activity was detected from the watersoluble and ethanol-precipitated crude extract (AG-1) of the root of Angelica gigas Nakai. The crude extract was fractionated into two fractions, an acidic AG-2 and a neutral AG-3 fraction by DEAE-cellulose adsorption. The two fractions contained polysaccharides of which M.W. were 10 Kdal and >2,000 Kdal respectively, proteins, and vanous inorganic components. The immunostimulating activities of two fractions were not reduced by proteinase K, acid or alkali treatment. The polysaccharides obtained from the root of A. gigas were mainly composed of arabinose, galactose, and galacturonic acid. These results indicated that immune-stimulating components of the root of A. gigas was a kind of pectic polysaccharides or arabinogalactans.

Original languageEnglish
Pages (from-to)254-261
Number of pages8
JournalKorean Journal of Pharmacognosy
Volume27
Issue number3
Publication statusPublished - 1996 Jan 1
Externally publishedYes

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Keywords

  • Angelica gigas
  • arabinogalactan
  • immuno-stimulating activity
  • mixed leukocyte reaction
  • pectic polysaccharide

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Ahn, K. S., Sim, W. S., Kim, H. M., Han, S. B., & Kim, I. H. (1996). Immunostimulating components from the root of Angelica gigas Nakai. Korean Journal of Pharmacognosy, 27(3), 254-261.