Impact of ABO incompatible kidney transplantation on living donor transplantation

Korean Organ Transplantation Registry Study Group

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: ABO incompatible kidney transplantation (ABOi-KT) is an important approach for overcoming donor shortages. We evaluated the effect of ABOi-KT on living donor KT. Methods: Two nationwide transplantation databases were used. We evaluated the impact of ABOi-KT on overall living donor transplant activity and spousal donation as subgroup analysis. In addition, we compared the clinical outcome between ABOi-KT and ABO compatible KT (ABOc-KT) from spousal donor, and performed a Cox proportional hazards regression analysis to define the risk factors affecting the allograft outcomes. Result: The introduction of ABOi-KT increased overall living donor KT by 12.2% and its portion was increased from 0.3% to 21.7% during study period. The ABOi-KT in living unrelated KT was two times higher than that of living related donor KT (17.8 vs.9.8%). Spousal donor was a major portion of living unrelated KT (77.6%) and ABOi-KT increased spousal donation from 10% to 31.5% in living donor KT. In addition, increasing rate ABOi-KT from spousal donor was 10 times higher than that of living related donor. The clinical outcome (incidence of acute rejection, allograft function, and allograft and patient survival rates) of ABOi-KT from spousal donor was comparable to that of ABOc-KT. Neither ABO incompatibility nor spousal donor was associated with acute rejection or allograft failure on multivariate analysis. Conclusions: ABOi-KT increased overall living donor KT, and ABOi-KT from spousal donor is rapidly increasing with favorable clinical outcomes.

Original languageEnglish
Article numbere0173878
JournalPLoS One
Volume12
Issue number3
DOIs
Publication statusPublished - 2017 Mar 1

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kidney transplant
Living Donors
Kidney Transplantation
Allografts
Transplantation
Tissue Donors
allografting
Transplants
Regression analysis
Hazards
graft rejection
multivariate analysis
regression analysis
risk factors
Multivariate Analysis
Survival Rate
survival rate
Regression Analysis
Databases

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Impact of ABO incompatible kidney transplantation on living donor transplantation. / Korean Organ Transplantation Registry Study Group.

In: PLoS One, Vol. 12, No. 3, e0173878, 01.03.2017.

Research output: Contribution to journalArticle

Korean Organ Transplantation Registry Study Group. / Impact of ABO incompatible kidney transplantation on living donor transplantation. In: PLoS One. 2017 ; Vol. 12, No. 3.
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title = "Impact of ABO incompatible kidney transplantation on living donor transplantation",
abstract = "Background: ABO incompatible kidney transplantation (ABOi-KT) is an important approach for overcoming donor shortages. We evaluated the effect of ABOi-KT on living donor KT. Methods: Two nationwide transplantation databases were used. We evaluated the impact of ABOi-KT on overall living donor transplant activity and spousal donation as subgroup analysis. In addition, we compared the clinical outcome between ABOi-KT and ABO compatible KT (ABOc-KT) from spousal donor, and performed a Cox proportional hazards regression analysis to define the risk factors affecting the allograft outcomes. Result: The introduction of ABOi-KT increased overall living donor KT by 12.2{\%} and its portion was increased from 0.3{\%} to 21.7{\%} during study period. The ABOi-KT in living unrelated KT was two times higher than that of living related donor KT (17.8 vs.9.8{\%}). Spousal donor was a major portion of living unrelated KT (77.6{\%}) and ABOi-KT increased spousal donation from 10{\%} to 31.5{\%} in living donor KT. In addition, increasing rate ABOi-KT from spousal donor was 10 times higher than that of living related donor. The clinical outcome (incidence of acute rejection, allograft function, and allograft and patient survival rates) of ABOi-KT from spousal donor was comparable to that of ABOc-KT. Neither ABO incompatibility nor spousal donor was associated with acute rejection or allograft failure on multivariate analysis. Conclusions: ABOi-KT increased overall living donor KT, and ABOi-KT from spousal donor is rapidly increasing with favorable clinical outcomes.",
author = "{Korean Organ Transplantation Registry Study Group} and Yu, {Ji Hyun} and Chung, {Byung Ha} and Yang, {Chul Woo} and Curie Ahn and Koo, {Tai Yeon} and Jeong, {Jong Cheol} and Jaeseok Yang and Choi, {Bum Soon} and Myung-Gyu Kim and Kim, {Yu Seun} and Kim, {Myung Soo} and Kwon, {Oh Jung} and Kim, {Sung Joo} and Kim, {Yeong Hoon} and Choi, {Soo Jin Na} and Chung, {Sang Young} and Cho, {Won Hyun}",
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T1 - Impact of ABO incompatible kidney transplantation on living donor transplantation

AU - Korean Organ Transplantation Registry Study Group

AU - Yu, Ji Hyun

AU - Chung, Byung Ha

AU - Yang, Chul Woo

AU - Ahn, Curie

AU - Koo, Tai Yeon

AU - Jeong, Jong Cheol

AU - Yang, Jaeseok

AU - Choi, Bum Soon

AU - Kim, Myung-Gyu

AU - Kim, Yu Seun

AU - Kim, Myung Soo

AU - Kwon, Oh Jung

AU - Kim, Sung Joo

AU - Kim, Yeong Hoon

AU - Choi, Soo Jin Na

AU - Chung, Sang Young

AU - Cho, Won Hyun

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Background: ABO incompatible kidney transplantation (ABOi-KT) is an important approach for overcoming donor shortages. We evaluated the effect of ABOi-KT on living donor KT. Methods: Two nationwide transplantation databases were used. We evaluated the impact of ABOi-KT on overall living donor transplant activity and spousal donation as subgroup analysis. In addition, we compared the clinical outcome between ABOi-KT and ABO compatible KT (ABOc-KT) from spousal donor, and performed a Cox proportional hazards regression analysis to define the risk factors affecting the allograft outcomes. Result: The introduction of ABOi-KT increased overall living donor KT by 12.2% and its portion was increased from 0.3% to 21.7% during study period. The ABOi-KT in living unrelated KT was two times higher than that of living related donor KT (17.8 vs.9.8%). Spousal donor was a major portion of living unrelated KT (77.6%) and ABOi-KT increased spousal donation from 10% to 31.5% in living donor KT. In addition, increasing rate ABOi-KT from spousal donor was 10 times higher than that of living related donor. The clinical outcome (incidence of acute rejection, allograft function, and allograft and patient survival rates) of ABOi-KT from spousal donor was comparable to that of ABOc-KT. Neither ABO incompatibility nor spousal donor was associated with acute rejection or allograft failure on multivariate analysis. Conclusions: ABOi-KT increased overall living donor KT, and ABOi-KT from spousal donor is rapidly increasing with favorable clinical outcomes.

AB - Background: ABO incompatible kidney transplantation (ABOi-KT) is an important approach for overcoming donor shortages. We evaluated the effect of ABOi-KT on living donor KT. Methods: Two nationwide transplantation databases were used. We evaluated the impact of ABOi-KT on overall living donor transplant activity and spousal donation as subgroup analysis. In addition, we compared the clinical outcome between ABOi-KT and ABO compatible KT (ABOc-KT) from spousal donor, and performed a Cox proportional hazards regression analysis to define the risk factors affecting the allograft outcomes. Result: The introduction of ABOi-KT increased overall living donor KT by 12.2% and its portion was increased from 0.3% to 21.7% during study period. The ABOi-KT in living unrelated KT was two times higher than that of living related donor KT (17.8 vs.9.8%). Spousal donor was a major portion of living unrelated KT (77.6%) and ABOi-KT increased spousal donation from 10% to 31.5% in living donor KT. In addition, increasing rate ABOi-KT from spousal donor was 10 times higher than that of living related donor. The clinical outcome (incidence of acute rejection, allograft function, and allograft and patient survival rates) of ABOi-KT from spousal donor was comparable to that of ABOc-KT. Neither ABO incompatibility nor spousal donor was associated with acute rejection or allograft failure on multivariate analysis. Conclusions: ABOi-KT increased overall living donor KT, and ABOi-KT from spousal donor is rapidly increasing with favorable clinical outcomes.

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