Impact of bifurcation stent technique on clinical outcomes in patients with a Medina 0,0,1 coronary bifurcation lesion: Results from the cobis (coronary bifurcation stenting) II registry

Woo Jin Jang, Young Bin Song, Joo Yong Hahn, Seung Hyuk Choi, Hyo Soo Kim, Cheol Woong Yu, Seung-Woon Rha, Yangsoo Jang, Ki Bae Seung, Hyeon Cheol Gwon

Research output: Contribution to journalArticle

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Abstract

Conclusions: In patients with a Medina 0,0,1 type bifurcation lesion, the 2-stent technique seems to be associated with a better clinical outcome compared with the 1-stent technique. These findings need to be confirmed in randomized controlled trials.

Objective: To compare the long-term clinical outcomes of patients treated with 1-versus 2-stent techniques for Medina 0,0,1 type bifurcation lesions.

Background: Little is known about clinical outcomes and optimal treatment strategies for Medina 0,0,1 type bifurcation lesions.

Methods: A total of 2,897 consecutive patients who underwent percutaneous coronary intervention using a drug-eluting stent for a coronary bifurcation lesion with a side branch (SB) ≥2.3 mm were enrolled from 18 centers in South Korea. We compared target lesion failure (TLF), defined as the composite of cardiac death, myocardial infarction, or target lesion revascularization (TLR) according to 1- or 2-stent techniques in the patients with a de novo Medina 0,0,1 type bifurcation lesion (n = 113, 3.9%).

Results: Fifty patients were treated with the 1-stent technique, and 63 patients with the 2-stent technique. During a median follow-up duration of 36.6 months, patients in the 1-stent technique group tended to have a higher incidence of TLR (3.2 versus 12.0%, P = 0.07) and TLF (4.8 versus 12.0%, P = 0.16) than those in the 2-stent technique group. Multivariate analysis revealed that the 1-stent technique was associated with a higher risk of TLR (hazard ratio [HR] 7.35; 95% confidence interval [CI] 1.27-42.5; P = 0.03) and TLF (HR 4.65; 95% CI1.01-21.6; P = 0.05) than the 2-stent technique.

Original languageEnglish
Pages (from-to)E43-E50
JournalCatheterization and Cardiovascular Interventions
Volume84
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

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Stents
Registries
Republic of Korea
Drug-Eluting Stents
Percutaneous Coronary Intervention
Multivariate Analysis
Randomized Controlled Trials
Myocardial Infarction
Confidence Intervals
Incidence

Keywords

  • Drug-eluting stent
  • Medina 0,0,1 lesion
  • Percutaneous coronary intervention
  • Stent technique

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Impact of bifurcation stent technique on clinical outcomes in patients with a Medina 0,0,1 coronary bifurcation lesion : Results from the cobis (coronary bifurcation stenting) II registry. / Jang, Woo Jin; Song, Young Bin; Hahn, Joo Yong; Choi, Seung Hyuk; Kim, Hyo Soo; Yu, Cheol Woong; Rha, Seung-Woon; Jang, Yangsoo; Seung, Ki Bae; Gwon, Hyeon Cheol.

In: Catheterization and Cardiovascular Interventions, Vol. 84, No. 5, 01.01.2014, p. E43-E50.

Research output: Contribution to journalArticle

Jang, Woo Jin ; Song, Young Bin ; Hahn, Joo Yong ; Choi, Seung Hyuk ; Kim, Hyo Soo ; Yu, Cheol Woong ; Rha, Seung-Woon ; Jang, Yangsoo ; Seung, Ki Bae ; Gwon, Hyeon Cheol. / Impact of bifurcation stent technique on clinical outcomes in patients with a Medina 0,0,1 coronary bifurcation lesion : Results from the cobis (coronary bifurcation stenting) II registry. In: Catheterization and Cardiovascular Interventions. 2014 ; Vol. 84, No. 5. pp. E43-E50.
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abstract = "Conclusions: In patients with a Medina 0,0,1 type bifurcation lesion, the 2-stent technique seems to be associated with a better clinical outcome compared with the 1-stent technique. These findings need to be confirmed in randomized controlled trials.Objective: To compare the long-term clinical outcomes of patients treated with 1-versus 2-stent techniques for Medina 0,0,1 type bifurcation lesions.Background: Little is known about clinical outcomes and optimal treatment strategies for Medina 0,0,1 type bifurcation lesions.Methods: A total of 2,897 consecutive patients who underwent percutaneous coronary intervention using a drug-eluting stent for a coronary bifurcation lesion with a side branch (SB) ≥2.3 mm were enrolled from 18 centers in South Korea. We compared target lesion failure (TLF), defined as the composite of cardiac death, myocardial infarction, or target lesion revascularization (TLR) according to 1- or 2-stent techniques in the patients with a de novo Medina 0,0,1 type bifurcation lesion (n = 113, 3.9{\%}).Results: Fifty patients were treated with the 1-stent technique, and 63 patients with the 2-stent technique. During a median follow-up duration of 36.6 months, patients in the 1-stent technique group tended to have a higher incidence of TLR (3.2 versus 12.0{\%}, P = 0.07) and TLF (4.8 versus 12.0{\%}, P = 0.16) than those in the 2-stent technique group. Multivariate analysis revealed that the 1-stent technique was associated with a higher risk of TLR (hazard ratio [HR] 7.35; 95{\%} confidence interval [CI] 1.27-42.5; P = 0.03) and TLF (HR 4.65; 95{\%} CI1.01-21.6; P = 0.05) than the 2-stent technique.",
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T1 - Impact of bifurcation stent technique on clinical outcomes in patients with a Medina 0,0,1 coronary bifurcation lesion

T2 - Results from the cobis (coronary bifurcation stenting) II registry

AU - Jang, Woo Jin

AU - Song, Young Bin

AU - Hahn, Joo Yong

AU - Choi, Seung Hyuk

AU - Kim, Hyo Soo

AU - Yu, Cheol Woong

AU - Rha, Seung-Woon

AU - Jang, Yangsoo

AU - Seung, Ki Bae

AU - Gwon, Hyeon Cheol

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Conclusions: In patients with a Medina 0,0,1 type bifurcation lesion, the 2-stent technique seems to be associated with a better clinical outcome compared with the 1-stent technique. These findings need to be confirmed in randomized controlled trials.Objective: To compare the long-term clinical outcomes of patients treated with 1-versus 2-stent techniques for Medina 0,0,1 type bifurcation lesions.Background: Little is known about clinical outcomes and optimal treatment strategies for Medina 0,0,1 type bifurcation lesions.Methods: A total of 2,897 consecutive patients who underwent percutaneous coronary intervention using a drug-eluting stent for a coronary bifurcation lesion with a side branch (SB) ≥2.3 mm were enrolled from 18 centers in South Korea. We compared target lesion failure (TLF), defined as the composite of cardiac death, myocardial infarction, or target lesion revascularization (TLR) according to 1- or 2-stent techniques in the patients with a de novo Medina 0,0,1 type bifurcation lesion (n = 113, 3.9%).Results: Fifty patients were treated with the 1-stent technique, and 63 patients with the 2-stent technique. During a median follow-up duration of 36.6 months, patients in the 1-stent technique group tended to have a higher incidence of TLR (3.2 versus 12.0%, P = 0.07) and TLF (4.8 versus 12.0%, P = 0.16) than those in the 2-stent technique group. Multivariate analysis revealed that the 1-stent technique was associated with a higher risk of TLR (hazard ratio [HR] 7.35; 95% confidence interval [CI] 1.27-42.5; P = 0.03) and TLF (HR 4.65; 95% CI1.01-21.6; P = 0.05) than the 2-stent technique.

AB - Conclusions: In patients with a Medina 0,0,1 type bifurcation lesion, the 2-stent technique seems to be associated with a better clinical outcome compared with the 1-stent technique. These findings need to be confirmed in randomized controlled trials.Objective: To compare the long-term clinical outcomes of patients treated with 1-versus 2-stent techniques for Medina 0,0,1 type bifurcation lesions.Background: Little is known about clinical outcomes and optimal treatment strategies for Medina 0,0,1 type bifurcation lesions.Methods: A total of 2,897 consecutive patients who underwent percutaneous coronary intervention using a drug-eluting stent for a coronary bifurcation lesion with a side branch (SB) ≥2.3 mm were enrolled from 18 centers in South Korea. We compared target lesion failure (TLF), defined as the composite of cardiac death, myocardial infarction, or target lesion revascularization (TLR) according to 1- or 2-stent techniques in the patients with a de novo Medina 0,0,1 type bifurcation lesion (n = 113, 3.9%).Results: Fifty patients were treated with the 1-stent technique, and 63 patients with the 2-stent technique. During a median follow-up duration of 36.6 months, patients in the 1-stent technique group tended to have a higher incidence of TLR (3.2 versus 12.0%, P = 0.07) and TLF (4.8 versus 12.0%, P = 0.16) than those in the 2-stent technique group. Multivariate analysis revealed that the 1-stent technique was associated with a higher risk of TLR (hazard ratio [HR] 7.35; 95% confidence interval [CI] 1.27-42.5; P = 0.03) and TLF (HR 4.65; 95% CI1.01-21.6; P = 0.05) than the 2-stent technique.

KW - Drug-eluting stent

KW - Medina 0,0,1 lesion

KW - Percutaneous coronary intervention

KW - Stent technique

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