Impact of both ends of the hemoglobin range on clinical outcomes in acute ischemic stroke

Young Ho Park, Beom Joon Kim, Jun Soon Kim, Mi Hwa Yang, Myung Suk Jang, Nayoung Kim, Moon Ku Han, Ji Sung Lee, Juneyoung Lee, Sang Yun Kim, Hee Joon Bae

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background and Purpose: Although both ends of the hemoglobin range may negatively influence clinical outcomes in acute ischemic stroke, most studies have examined the linear relationship or focused on the lower end of the range. Furthermore, it is unclear whether hemoglobin concentrations at different time points during hospitalization correlate with clinical outcomes in the same manner. Methods: We identified 2681 consecutive patients with acute ischemic stroke from a prospective stroke registry database and grouped them into hemoglobin concentration quintiles using the following 5 indices: initial, nadir, time-averaged, discharge hemoglobin, and hemoglobin drop. To examine the effect of both ends of hemoglobin range, the third quintile was selected as a reference category except for hemoglobin drop, for which the first quintile was used. As outcome variables, 3-month modified Rankin Scale as an ordinal scale and 3-month mortality were used. Results: With respect to higher modified Rankin Scale scores, the adjusted odds ratios and 95% confidence intervals of the first quintiles of initial, nadir, time-averaged, and discharge hemoglobin were 1.74 (1.31-2.31), 2.64 (2.09-3.33), 1.81 (1.42-2.30), and 1.65 (1.29-2.13), respectively. The opposite ends of these hemoglobin indices were not significantly associated. The adjusted odds ratio of the fifth quintile of hemoglobin drop (greatest hemoglobin drop) was 2.09 (1.51-2.89). The mortality analysis showed similar results except for initial hemoglobin. Conclusions: In acute ischemic stroke, poor outcome was related to the lower but not the higher end of the hemoglobin range, regardless of when and how hemoglobin concentrations were measured.

Original languageEnglish
Pages (from-to)3220-3222
Number of pages3
JournalStroke
Volume44
Issue number11
DOIs
Publication statusPublished - 2013 Nov 1

Fingerprint

Hemoglobins
Stroke
Odds Ratio
Mortality
Registries
Hospitalization
Databases
Confidence Intervals

Keywords

  • Cerebral infarction
  • Functional outcome
  • Hemoglobins

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

Cite this

Park, Y. H., Kim, B. J., Kim, J. S., Yang, M. H., Jang, M. S., Kim, N., ... Bae, H. J. (2013). Impact of both ends of the hemoglobin range on clinical outcomes in acute ischemic stroke. Stroke, 44(11), 3220-3222. https://doi.org/10.1161/STROKEAHA.113.002672

Impact of both ends of the hemoglobin range on clinical outcomes in acute ischemic stroke. / Park, Young Ho; Kim, Beom Joon; Kim, Jun Soon; Yang, Mi Hwa; Jang, Myung Suk; Kim, Nayoung; Han, Moon Ku; Lee, Ji Sung; Lee, Juneyoung; Kim, Sang Yun; Bae, Hee Joon.

In: Stroke, Vol. 44, No. 11, 01.11.2013, p. 3220-3222.

Research output: Contribution to journalArticle

Park, YH, Kim, BJ, Kim, JS, Yang, MH, Jang, MS, Kim, N, Han, MK, Lee, JS, Lee, J, Kim, SY & Bae, HJ 2013, 'Impact of both ends of the hemoglobin range on clinical outcomes in acute ischemic stroke', Stroke, vol. 44, no. 11, pp. 3220-3222. https://doi.org/10.1161/STROKEAHA.113.002672
Park, Young Ho ; Kim, Beom Joon ; Kim, Jun Soon ; Yang, Mi Hwa ; Jang, Myung Suk ; Kim, Nayoung ; Han, Moon Ku ; Lee, Ji Sung ; Lee, Juneyoung ; Kim, Sang Yun ; Bae, Hee Joon. / Impact of both ends of the hemoglobin range on clinical outcomes in acute ischemic stroke. In: Stroke. 2013 ; Vol. 44, No. 11. pp. 3220-3222.
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AU - Kim, Beom Joon

AU - Kim, Jun Soon

AU - Yang, Mi Hwa

AU - Jang, Myung Suk

AU - Kim, Nayoung

AU - Han, Moon Ku

AU - Lee, Ji Sung

AU - Lee, Juneyoung

AU - Kim, Sang Yun

AU - Bae, Hee Joon

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N2 - Background and Purpose: Although both ends of the hemoglobin range may negatively influence clinical outcomes in acute ischemic stroke, most studies have examined the linear relationship or focused on the lower end of the range. Furthermore, it is unclear whether hemoglobin concentrations at different time points during hospitalization correlate with clinical outcomes in the same manner. Methods: We identified 2681 consecutive patients with acute ischemic stroke from a prospective stroke registry database and grouped them into hemoglobin concentration quintiles using the following 5 indices: initial, nadir, time-averaged, discharge hemoglobin, and hemoglobin drop. To examine the effect of both ends of hemoglobin range, the third quintile was selected as a reference category except for hemoglobin drop, for which the first quintile was used. As outcome variables, 3-month modified Rankin Scale as an ordinal scale and 3-month mortality were used. Results: With respect to higher modified Rankin Scale scores, the adjusted odds ratios and 95% confidence intervals of the first quintiles of initial, nadir, time-averaged, and discharge hemoglobin were 1.74 (1.31-2.31), 2.64 (2.09-3.33), 1.81 (1.42-2.30), and 1.65 (1.29-2.13), respectively. The opposite ends of these hemoglobin indices were not significantly associated. The adjusted odds ratio of the fifth quintile of hemoglobin drop (greatest hemoglobin drop) was 2.09 (1.51-2.89). The mortality analysis showed similar results except for initial hemoglobin. Conclusions: In acute ischemic stroke, poor outcome was related to the lower but not the higher end of the hemoglobin range, regardless of when and how hemoglobin concentrations were measured.

AB - Background and Purpose: Although both ends of the hemoglobin range may negatively influence clinical outcomes in acute ischemic stroke, most studies have examined the linear relationship or focused on the lower end of the range. Furthermore, it is unclear whether hemoglobin concentrations at different time points during hospitalization correlate with clinical outcomes in the same manner. Methods: We identified 2681 consecutive patients with acute ischemic stroke from a prospective stroke registry database and grouped them into hemoglobin concentration quintiles using the following 5 indices: initial, nadir, time-averaged, discharge hemoglobin, and hemoglobin drop. To examine the effect of both ends of hemoglobin range, the third quintile was selected as a reference category except for hemoglobin drop, for which the first quintile was used. As outcome variables, 3-month modified Rankin Scale as an ordinal scale and 3-month mortality were used. Results: With respect to higher modified Rankin Scale scores, the adjusted odds ratios and 95% confidence intervals of the first quintiles of initial, nadir, time-averaged, and discharge hemoglobin were 1.74 (1.31-2.31), 2.64 (2.09-3.33), 1.81 (1.42-2.30), and 1.65 (1.29-2.13), respectively. The opposite ends of these hemoglobin indices were not significantly associated. The adjusted odds ratio of the fifth quintile of hemoglobin drop (greatest hemoglobin drop) was 2.09 (1.51-2.89). The mortality analysis showed similar results except for initial hemoglobin. Conclusions: In acute ischemic stroke, poor outcome was related to the lower but not the higher end of the hemoglobin range, regardless of when and how hemoglobin concentrations were measured.

KW - Cerebral infarction

KW - Functional outcome

KW - Hemoglobins

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