Impact of high lipoprotein(a) levels on in-stent restenosis and long-term clinical outcomes of angina pectoris patients undergoing percutaneous coronary intervention with drug-eluting stents in Asian population

Sang Ho Park, Seung-Woon Rha, Byoung Geol Choi, Ji Young Park, Ung Jeon, Hong Seog Seo, Eung Ju Kim, Jin Oh Na, Cheol Ung Choi, Jin Won Kim, Hong Euy Lim, Chang Gyu Park, Dong Joo Oh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Lipoprotein(a) (Lp(a)) is known to be associated with cardiovascular complications and atherothrombotic properties in general populations. However, it has not been examined whether Lp(a) levels are able to predict adverse cardiovascular outcomes in patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES). A total of 595 consecutive patients with angina pectoris who underwent elective PCI with DES were enrolled from 2004 to 2010. The patients were divided into two groups according to the levels of Lp(a): Lp(a) < 50 mg/dL (n = 485 patients), and Lp(a) ≥ 50 mg/dL (n = 111 patients). The 6-9-month angiographic outcomes and 3-year cumulative major clinical outcomes were compared between the two groups. Binary restenosis occurred in 26 of 133 lesions (19.8%) in the high Lp(a) group and 43 of 550 lesions (7.9%) in the low Lp(a) group (P = 0.001). In multivariate analysis, the reference vessel diameter, low density lipoprotein cholesterol, total lesion length, and Lp(a) ≥ 50 mg/dL were predictors of binary restenosis. In the Cox proportional hazards regression analysis, Lp(a) > 50 mg/dL was significantly associated with the 3-year adverse clinical outcomes including any myocardial infarction, revascularization (target lesion revascularization (TLR) and target vessel revascularization (TVR)), TLR-major adverse cardiac events (MACEs), TVR-MACE, and All-MACEs. In our study, high Lp(a) level ≥ 50 mg/dL in angina pectoris patients undergoing elective PCI with DES was significantly associated with binary restenosis and 3-year adverse clinical outcomes in an Asian population.

Original languageEnglish
Pages (from-to)588-595
Number of pages8
JournalClinical and Experimental Pharmacology and Physiology
Volume42
Issue number6
DOIs
Publication statusPublished - 2015 Jun 1

Keywords

  • Angina
  • Coronary
  • Lipoprotein(a)
  • Restenosis
  • Stents

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Pharmacology

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