Impact of insulin resistance on 1-year clinical outcomes in non-diabetic patients undergoing percutaneous coronary intervention with drug-eluting stents

In Kyeom Hwang, Yun Kyung Kim, Seung-Woon Rha, Ji Eun Ra, Bong Soo Seo, Ji Kyoung Lee, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Seong Woo Han, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Sang Myung Choi, Byoung Gy Chae, Sung Jin Kim, Seong Gyu Yoon, Il Woo Suh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Insulin resistance (IR) is known to be a risk factor for coronary artery disease (CAD). We aimed to evaluate the impact of IR on 1-year clinical outcomes in non-diabetic CAD patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DESs). Methods and results: A total of 229 consecutive non-diabetic CAD patients treated with DESs were enrolled. Study population was divided into IR group [homeostasis model assessment (HOMA) index ≥ 2.5, n= 54] and non-IR group (HOMA index < 2.5, n= 175). Baseline clinical and procedural characteristics were similar between the groups except higher incidence of high-sensitivity C-reactive protein and lower incidence of multivessel disease as the target vessel in the non-IR group. There was a trend toward longer restenosis lesion length in the IR group at 6 months angiographic follow up but composite major clinical outcomes up to 1 year were similar between the two groups. Conclusions: Despite worse trend in angiographic outcomes in the IR group (HOMA index ≥ 2.5), it was not translated into worse 1-year major clinical outcomes following PCI with DESs as compared to the non-IR group.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalJournal of Cardiology
Volume61
Issue number2
DOIs
Publication statusPublished - 2013 Feb 1

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Drug-Eluting Stents
Percutaneous Coronary Intervention
Insulin Resistance
Coronary Artery Disease
Homeostasis
Incidence
C-Reactive Protein
Population

Keywords

  • Drug-eluting stent
  • Insulin resistance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Impact of insulin resistance on 1-year clinical outcomes in non-diabetic patients undergoing percutaneous coronary intervention with drug-eluting stents. / Hwang, In Kyeom; Kim, Yun Kyung; Rha, Seung-Woon; Ra, Ji Eun; Seo, Bong Soo; Lee, Ji Kyoung; Na, Jin Oh; Choi, Cheol Ung; Lim, Hong Euy; Han, Seong Woo; Kim, Eung Ju; Park, Chang Gyu; Seo, Hong Seog; Oh, Dong Joo; Choi, Sang Myung; Chae, Byoung Gy; Kim, Sung Jin; Yoon, Seong Gyu; Suh, Il Woo.

In: Journal of Cardiology, Vol. 61, No. 2, 01.02.2013, p. 113-116.

Research output: Contribution to journalArticle

Hwang, In Kyeom ; Kim, Yun Kyung ; Rha, Seung-Woon ; Ra, Ji Eun ; Seo, Bong Soo ; Lee, Ji Kyoung ; Na, Jin Oh ; Choi, Cheol Ung ; Lim, Hong Euy ; Han, Seong Woo ; Kim, Eung Ju ; Park, Chang Gyu ; Seo, Hong Seog ; Oh, Dong Joo ; Choi, Sang Myung ; Chae, Byoung Gy ; Kim, Sung Jin ; Yoon, Seong Gyu ; Suh, Il Woo. / Impact of insulin resistance on 1-year clinical outcomes in non-diabetic patients undergoing percutaneous coronary intervention with drug-eluting stents. In: Journal of Cardiology. 2013 ; Vol. 61, No. 2. pp. 113-116.
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abstract = "Background: Insulin resistance (IR) is known to be a risk factor for coronary artery disease (CAD). We aimed to evaluate the impact of IR on 1-year clinical outcomes in non-diabetic CAD patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DESs). Methods and results: A total of 229 consecutive non-diabetic CAD patients treated with DESs were enrolled. Study population was divided into IR group [homeostasis model assessment (HOMA) index ≥ 2.5, n= 54] and non-IR group (HOMA index < 2.5, n= 175). Baseline clinical and procedural characteristics were similar between the groups except higher incidence of high-sensitivity C-reactive protein and lower incidence of multivessel disease as the target vessel in the non-IR group. There was a trend toward longer restenosis lesion length in the IR group at 6 months angiographic follow up but composite major clinical outcomes up to 1 year were similar between the two groups. Conclusions: Despite worse trend in angiographic outcomes in the IR group (HOMA index ≥ 2.5), it was not translated into worse 1-year major clinical outcomes following PCI with DESs as compared to the non-IR group.",
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AU - Kim, Yun Kyung

AU - Rha, Seung-Woon

AU - Ra, Ji Eun

AU - Seo, Bong Soo

AU - Lee, Ji Kyoung

AU - Na, Jin Oh

AU - Choi, Cheol Ung

AU - Lim, Hong Euy

AU - Han, Seong Woo

AU - Kim, Eung Ju

AU - Park, Chang Gyu

AU - Seo, Hong Seog

AU - Oh, Dong Joo

AU - Choi, Sang Myung

AU - Chae, Byoung Gy

AU - Kim, Sung Jin

AU - Yoon, Seong Gyu

AU - Suh, Il Woo

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N2 - Background: Insulin resistance (IR) is known to be a risk factor for coronary artery disease (CAD). We aimed to evaluate the impact of IR on 1-year clinical outcomes in non-diabetic CAD patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DESs). Methods and results: A total of 229 consecutive non-diabetic CAD patients treated with DESs were enrolled. Study population was divided into IR group [homeostasis model assessment (HOMA) index ≥ 2.5, n= 54] and non-IR group (HOMA index < 2.5, n= 175). Baseline clinical and procedural characteristics were similar between the groups except higher incidence of high-sensitivity C-reactive protein and lower incidence of multivessel disease as the target vessel in the non-IR group. There was a trend toward longer restenosis lesion length in the IR group at 6 months angiographic follow up but composite major clinical outcomes up to 1 year were similar between the two groups. Conclusions: Despite worse trend in angiographic outcomes in the IR group (HOMA index ≥ 2.5), it was not translated into worse 1-year major clinical outcomes following PCI with DESs as compared to the non-IR group.

AB - Background: Insulin resistance (IR) is known to be a risk factor for coronary artery disease (CAD). We aimed to evaluate the impact of IR on 1-year clinical outcomes in non-diabetic CAD patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DESs). Methods and results: A total of 229 consecutive non-diabetic CAD patients treated with DESs were enrolled. Study population was divided into IR group [homeostasis model assessment (HOMA) index ≥ 2.5, n= 54] and non-IR group (HOMA index < 2.5, n= 175). Baseline clinical and procedural characteristics were similar between the groups except higher incidence of high-sensitivity C-reactive protein and lower incidence of multivessel disease as the target vessel in the non-IR group. There was a trend toward longer restenosis lesion length in the IR group at 6 months angiographic follow up but composite major clinical outcomes up to 1 year were similar between the two groups. Conclusions: Despite worse trend in angiographic outcomes in the IR group (HOMA index ≥ 2.5), it was not translated into worse 1-year major clinical outcomes following PCI with DESs as compared to the non-IR group.

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