Impact of insulin resistance on 1-year clinical outcomes in non-diabetic patients undergoing percutaneous coronary intervention with drug-eluting stents

In Kyeom Hwang, Yun Kyung Kim, Seung Woon Rha, Ji Eun Ra, Bong Soo Seo, Ji Kyoung Lee, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Seong Woo Han, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Sang Myung Choi, Byoung Gy Chae, Sung Jin Kim, Seong Gyu Yoon, Il Woo Suh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Insulin resistance (IR) is known to be a risk factor for coronary artery disease (CAD). We aimed to evaluate the impact of IR on 1-year clinical outcomes in non-diabetic CAD patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DESs). Methods and results: A total of 229 consecutive non-diabetic CAD patients treated with DESs were enrolled. Study population was divided into IR group [homeostasis model assessment (HOMA) index ≥ 2.5, n= 54] and non-IR group (HOMA index < 2.5, n= 175). Baseline clinical and procedural characteristics were similar between the groups except higher incidence of high-sensitivity C-reactive protein and lower incidence of multivessel disease as the target vessel in the non-IR group. There was a trend toward longer restenosis lesion length in the IR group at 6 months angiographic follow up but composite major clinical outcomes up to 1 year were similar between the two groups. Conclusions: Despite worse trend in angiographic outcomes in the IR group (HOMA index ≥ 2.5), it was not translated into worse 1-year major clinical outcomes following PCI with DESs as compared to the non-IR group.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalJournal of Cardiology
Volume61
Issue number2
DOIs
Publication statusPublished - 2013 Feb

Keywords

  • Drug-eluting stent
  • Insulin resistance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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