Impact of left ventricular hypertrophy on longterm clinical outcomes in hypertensive patients who underwent successful percutaneous coronary intervention with drug-eluting stents

Yong Hoon Kim, Ae Young Her, Byoung Geol Choi, Se Yeon Choi, Jae Kyeong Byun, Man Jong Baek, Yang Gi Ryu, Yoonjee Park, Ahmed Mashaly, Won Young Jang, Woohyeun Kim, Jah Yeon Choi, Eun Jin Park, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Seung Woon Rha

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Left ventricular hypertrophy (LVH) is associated with increased risk for vascular events and mortality. This study investigated 8-year clinical outcomes of hypertensive patients with LVH who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DES) compared with hypertensive patients without LVH. A total of 1704 consecutive hypertensive patients who underwent PCI from 2004 to 2014 were enrolled. We classified them into either the LVH group (n=406) or the control group (without LVH, n=1298). LVH was defined by LV mass index > 115g/m2 in men and>95g/m2 in women. After propensity score matched (PSM) analysis, 2 PSM groups (366 pairs, n=732, c-statistic=0.629) were generated. For up to 8 years, the LVH group showed a higher incidence of cardiac death (4.4% vs 1.2%, log-rank P=.023, hazard ratio: 3.371, 95% confidence interval: 1.109-10.25; P=.032) compared with the control group. However, there were no significant differences between the 2 groups in the incidence of total death, myocardial infarction, revascularization, and major adverse cardiac events up to 8 years. LVH in hypertensive patients who underwent successful PCI with DES was associated with higher incidence of cardiac death up to 8 years of follow-up. More careful managements and clinical follow-up are needed and treatment strategies should specifically focus to target prevention and reversal of LVH in hypertensive patients.

Original languageEnglish
Article numbere12067
JournalMedicine (United States)
Volume97
Issue number35
DOIs
Publication statusPublished - 2018 Aug 1

Keywords

  • Coronary artery disease
  • Hypertension
  • Left ventricular hypertrophy
  • Outcome

ASJC Scopus subject areas

  • Medicine(all)

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